Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease

Status: Completed
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The objective of this study is to further the understanding and application of 60Hz subthalamic deep brain stimulation (STN-DBS) in Parkinson's patients with gait disorder. The investigators will achieve this through 2 study aims: 1. Determine the impact of 60Hz subthalamic deep brain stimulation on gait kinematics using wearable sensors 2. Develop machine learning models to predict optimal subthalamic deep brain stimulation frequency based on wearable sensors

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 80
Healthy Volunteers: f
View:

• Male or female, aged 21-80

• Patients diagnosed with Parkinson's disease (PD)

• PD subjects who have bilateral STN-DBS (greater than 3 months) or in the preoperative stage of being implanted with bilateral STN-DBS

• Have underlying gait disorder

• Currently treated with oral levodopa therapy

• Willingness to comply with all study procedures

Locations
United States
New York
Northwell Health
Great Neck
Time Frame
Start Date: 2020-01-15
Completion Date: 2022-08-31
Participants
Target number of participants: 24
Treatments
Experimental: Deep Brain Stimulation(DBS) OFF Medication
Subthalamic-DBS in the Levodopa OFF state.
Experimental: Deep Brain Stimulation(DBS) ON Medication
Subthalamic-DBS in the Levodopa ON state.
Sponsors
Collaborators: The University of Tennessee, Knoxville, National Institute of Neurological Disorders and Stroke (NINDS)
Leads: Northwell Health

This content was sourced from clinicaltrials.gov