Feasibility of Vertebral Body Sparing Intensity Modulated Proton Therapy Craniospinal Irradiation With in Vivo Range Verification in Growing Children
Status: Completed
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This trial studies the feasibility of using intensity modulated proton therapy to deliver craniospinal irradiation while avoiding the bones of the vertebral column. Intensity modulated proton therapy is an advanced radiation therapy modality that uses high energy protons to kill cancer cells and shrink tumors, and may reduce the side effects of treatment by reducing radiation exposure to the spinal column.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 18
Healthy Volunteers: f
View:
• Pathologic diagnosis of central nervous system malignancy requiring craniospinal irradiation.
• Signed informed consent and assent when indicated.
Locations
United States
Georgia
Emory Proton Therapy Center
Atlanta
Emory University Hospital/Winship Cancer Institute
Atlanta
Time Frame
Start Date: 2019-12-16
Completion Date: 2024-02-09
Participants
Target number of participants: 10
Treatments
Experimental: Treatment (intensity modulated proton therapy)
Patients undergo intensity modulated proton therapy once daily over 30 fractions and also undergo MRI over 20 minutes during fractions 7, 13, 20, and 30 of radiation in the absence of disease progression or unacceptable toxicity.
Authors
Sponsors
Collaborators: National Institutes of Health (NIH), National Cancer Institute (NCI)
Leads: Emory University