Maternal-fetal Immune Responses to Fetal Surgery
Status: Active_not_recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the effectiveness of these procedures. The investigators aim to understand the effects of surgery on the maternal and fetal immune system and whether immune activation may be causing some of these infants to be born prematurely.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:
• Maternal age ≥18 years
• Pregnant with a congenital anomaly diagnosis AND undergoing fetal intervention in utero
• Delivery planned at Mayo Clinic, Rochester MN
• Maternal age ≥18 years
• Pregnant with normal ultrasound findings
• Delivery planned at Mayo Clinic, Rochester MN
Locations
United States
Minnesota
Mayo Clinic in Rochester, Minnesota
Rochester
Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati
Texas
University of Texas Houston
Houston
Time Frame
Start Date: 2022-03-24
Completion Date: 2025-03-31
Participants
Target number of participants: 60
Treatments
Fetal surgical intervention group
Pregnant adult women carrying a fetus with a diagnosed congenital anomaly and scheduled to undergo fetal surgical intervention at Mayo Clinic.
Control group - normal pregnancy
Pregnant adult women with normal ultrasound findings. These women will be matched with the subjects enrolled in the intervention cohort for parity, maternal age, ethnicity, fetal sex and gestational age at time of surgical intervention.
Authors
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic