Optimization of Targeted Anticancer Therapies: a Systematic Collection and Modeling of Pharmacokinetic Data and Elaboration of an Adherence Program
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The study includes an observational pharmacokinetic study and an interventional medication adherence study. The purpose of this study is 1) to describe the concentration-time profiles of targeted anticancer drugs and to characterize the concentration-effect/toxicity relationships in the target population of patients (observational study) and 2) to characterize patterns of adherence to oral targeted anticancer drugs and identify key-driver modifiable adherence factors in patients participating in an adherence program (interventional study).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Cancer patients to whom a targeted anticancer therapy is prescribed
Locations
Other Locations
Switzerland
CHUV
RECRUITING
Lausanne
Contact Information
Primary
Chantal Csajka, PharmD, PhD
chantal.csajka@chuv.ch
21 314 42 63
Time Frame
Start Date: 2015-05
Estimated Completion Date: 2030-12
Participants
Target number of participants: 500
Treatments
No_intervention: Standard care
Patients in the standard care arm will use an electronic adherence monitor (MEMS®) without any feedback (electronic data will be blinded to patients, clinicians and investigators until the analysis)
Experimental: Adherence program
Patients in the adherence program will use the MEMS® and the pharmacist will provide an electronic feedback on medication adherence since the last visit. The identified determinants of medication adherence will be discussed with the patient.
Sponsors
Collaborators: Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland, Krebsforschung Schweiz, Bern, Switzerland
Leads: Centre Hospitalier Universitaire Vaudois