Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD): A Prospective, Multicenter, Randomized, Controlled Trial
Who is this study for? Patients with coronary multi-vessel disease
What treatments are being studied? Clopidogrel and Aspirin dual-antiplatelet therapy
Status: Active_not_recruiting
Location: See all (110) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study is a prospective, multicenter, parallel, open-label, randomized, controlled, superiority trial. It is planned to recruit 8,250 patients with multi-vessel disease(MVD), and the patients will be followed-up for at least 12 months after being implanted with a drug-eluting stent (DES) at one of 100 different centers. All patients will be randomly divided into the treatment group and control group on a 1:1 basis, based on a complete randomization.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• The enrolled subjects must meet all of the following criteria:
‣ Aged 18-75 years old (inclusive).
⁃ Patients with MVD who underwent DES implantation for 12 months.
⁃ Patients have been treated with aspirin and can tolerant of aspirin at doses of 75-150 mg/day as maintenance therapy during the study period.
⁃ Patients have signed informed consent.
Locations
Other Locations
China
Affiliated Beijing Luhe Hospital of Capital Medical University
Beijing
Cangzhou Central Hospital
Cangzhou
The Second Affiliated Hospital of Jilin University
Chang Chun
The Third Affiliated Hospital of Jilin University
Chang Chun
Affiliated Hospital of Changchun Traditional Chinese Medicine University
Changchun
The First Affiliated Hospital of Jilin University
Changchun
The Third Xiangya Hospital of Central South University
Changsha
Affiliated Hospital of Chengde Medical University
Chengde
The First Affiliated Hospital of Chongqing Medical University
Chongqing
The Second Affiliated Hospital of Army Medical University
Chongqing
Dalian Municipal Cental Hospital
Dalian
The First Affiliated Hospital of Dalian Medical University
Dalian
Daqing Long Nan Hospital
Daqing
Daqing Oilfield General Hospital
Daqing
Daqing People's Hosipital
Daqing
Dazhou Central Hospital
Dazhou
Feicheng Hospital of Shandong Guoxin Yiyang Group
Fengcheng
First People's Hospital of Fuzhou
Fuzhou
Fujian Provincial Hospital
Fuzhou
The First Affiliated Hospital, Sun Yat-Sen University
Guangzhou
Haikou People's Hospital
Haikou
Hainan General Hospital
Haikou
The Second Affiliated Hospital of Hainan Medical University
Haikou
Harbin 242 Hospital
Harbin
Harbin First Hospital
Harbin
Harbin Second Hospital
Harbin
Heilongjiang Province Hospital
Harbin
Shuangcheng People's Hospital
Harbin
The Fourth Affiliated Hospital of Harbin Medical University
Harbin
The Second Affiliated Hospital of Harbin Medical University
Harbin
The Second Cancer Hospital of Heilongjiang Province
Harbin
Hegang Mining Group General Hospital
Hegang
Hegang People's Hospital
Hegang
Heilongjiang Provincial Agricultural Reclamation Baoquanling Administration Center Hospital
Hegang
Nenjiang People's Hospital
Heihe
Harrison International Peace Hospital
Hengshui
The First Affiliated Hospital of University of South China
Hengyang
Hezhou People's Hospital
Hezuo
Hulunbeir People's Hospital
Hulunbeir
The Central Hospital of Jiamusi City
Jiamusi
The First Affiliated Hospital of Jamusi University
Jiamusi
The Jiansanjiang People's Hospital of Heilongjiang Land Reclamation
Jiamusi
General Hospital of Jihua Group Company
Jilin
Jilin Central Hospital
Jilin
Jilin Integrated Traditional Chinese and Western Medicine Hospital
Jilin
Qilu Hospital of Shandong University
Jinan
Shandong Second Provincial General Hospital
Jinan
The Fifth People's Hospital of Jinan
Jinan
The Fourth People's Hospital of Jinan
Jinan
Yanzhou District People's Hospital
Jining
Jixi Jikuang Hospital
Jixi
Jixi People's Hospital
Jixi
Kaifeng Central Hospital
Kaifeng
The First People's Hospital of Lianyungang
Lianyungang
The Second People's Hospital of Liaocheng
Liaocheng
Mishan People's Hospital
Mishan
Hongqi Hospital of Mudanjiang Medical University
Mudanjiang
Mudanjiang Administration Center Hospital of Heilongjiang Land Reclamation
Mudanjiang
Mudanjiang Cardiovascular Hospital
Mudanjiang
Mudanjiang City Second People's Hospital
Mudanjiang
Mudanjiang First People's Hospital
Mudanjiang
Zhongda Hospital Southeast University
Nanjing
Nanyang First People's Hospital
Nanyang
The First Affiliated Hospital of Nanyang Medical College
Nanyang
Inner Mongolia People's Hospital
Neimeng
Pizhou People's Hospital
Pizhou
Puyang People's Hospital
Puyang
Pingquan County Hospital
Qingyang
Qiqihar Jianhua Hospital
Qiqihar
The First Affiliated Hospital of Qiqihar Medical University
Qiqihar
The Third Affiliated Hospital of Qiqihar Medical University
Qiqihar
Wusong hospital Affiliated Zhongshan Hospital of Fudan University
Shanghai
Central Hospital of Yongcheng
Shangqiu
The First People's Hospital of Shangqiu
Shangqiu
Shenzhen People's Hospital
Shenzhen
The Second Hospital of Hebei Medical University
Shijiazhuang
The Third Hospital of Shijiazhuang
Shijiazhuang
Emergency General Hospital of Shuangyashan
Shuangyashan
Hongxinglong Central Hospital
Shuangyashan
Shuangyashan People's Hospital
Shuangyashan
The People's Hospital of Baoqing
Shuangyashan
Songyuan Central Hospital
Songyuan
Suihua First Hospital
Suihua
Taian City Central Hospital
Tai'an
Tangshan Central Hospital
Tangshan
Tianjin Chest Hospital
Tianjin
Tianjin Medical University General Hospital
Tianjin
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi
Xinjiang Uiger Municipal People's Hospital
Ürümqi
Renmin Hospital of Wuhan University
Wuhan
The Fourth Hospital of Wuhan
Wuhan
Zhongnan Hospital of Wuhan University
Wuhan
Xiamen Fifth Hospital
Xiamen
Shanxi Provincial People's Hospital
Xian
Daxing'anling Prefecture People's Hospital
Xing'anling
The Second Affiliated Hospital of Xingtai Medical College
Xingtai
Xingtai Third Hospital
Xingtai
The Second People's Hospital of Xinxiang City
Xinxiang
Yichang First People's Hospital
Yichang
Tieli People's Hospital
Yichun
Yichun First Hospital
Yichun
Yichun Forestry Central Hospital
Yichun
General Hospital of Ningxia Medical University
Yinchuan
Yongcheng People's Hospital
Yongcheng
The First Affiliated Hospital of Zhengzhou University
Zhengzhou
The Seventh People's Hospital of Zhengzhou
Zhengzhou
Guangdong Provincial People's Hospital
Zhongshan
The Eighth Affiliated Hospital, Sun Yat-Sen University
Zhongshan
Dancheng People's Hospital
Zhoukou
Affiliated Hospital of Zunyi Medical University
Zunyi
Time Frame
Start Date: 2020-10-27
Completion Date: 2025-04-30
Participants
Target number of participants: 8250
Treatments
Placebo_comparator: Aspirin monotherapy
Patients will receive aspirin monotherapy without co-administration of clopidogrel for 12 months after randomization.
Experimental: Clopidogrel and Aspirin dual-antiplatelet therapy
Patients will receive co-administration of clopidogrel and aspirin for 12 months after randomization.
Authors
LI Zhang, Ying Li, Shan Gao, Yong Liu, Zhenjiang Ding, Chunjie Li, Jian Yang, Guoqiang Gu, Huifang Tang, Xiang Xie, Shi Yin, Genshan Ma, Jianmin Yang, Qing Yang, Xiling Shou, Yitong Ma, Hongyu Shi, Huanyi Zhang, Yin Liu, Lijun Wang, Qian Tong, Jun Jin, Yuquan He, Yansong Guo, Jinying Zhang, Zheng Wang, Jun Zhang, Bo Yu
Related Therapeutic Areas
Sponsors
Collaborators: Chinese Society of Cardiology, Lepu Medical Technology (Beijing) Co., Ltd.
Leads: Harbin Medical University