STOP-TIC Study: Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT

Status: Completed

Location: See location...

Intervention Type: Behavioral, Device

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

The investigator will apply 16 sessions of repetitive transcranial magnetic stimulation (rTMS) over 4 consecutive days for adult patients suffering from Tourette's Syndrome. Following rTMS, patients will undergo 8 sessions of Comprehensive Behavioral Intervention for Tics (CBIT) over 10 weeks via telemedicine. Clinical improvement in tic severity will be the primary outcome measure. Secondary outcome measures including underlying physiological effects will be measured via functional magnetic resonance imaginge (fMRI), high-density electroencephalograhy (HD-EEG), and TMS.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 85

Healthy Volunteers: f

View:

• Any patient diagnosed with Tourette Syndrome \> 18 years of age with moderate tic severity.

• Participants will be allowed to continue oral medications that they are taking for TS concurrently but will not be allowed to change their concurrent medication regimen throughout the duration of the study

Locations

United States

Florida

Fixel Neurologic Institute

Gainesville

Time Frame

Start Date: 2021-12-17

Completion Date: 2023-01-18

Participants

Target number of participants: 3

Treatments

Experimental: Active rTMS Group

Patients will be seated in a comfortable reclined chair. The neurostimulation protocol will include 1-Hz rTMS over the bilateral SMA at 110% resting motor threshold (RMT). The SMA will be identified as 4 cm anterior to the vertex (Cz in standard 10-20 EEG setup). Each session will consist of 6 trains lasting 5 minutes each (300 pulses per train) with an intertrain interval of 1 minute for a total duration of 35 minutes (1800 pulses). Patients will receive 4 sessions each day on 4 consecutive days for a total of 16 sessions. Daily duration of this study protocol should last approximately 170 minutes including a 10 minute break in between each session.

Authors

Jessica Frey

Related Therapeutic Areas

Transient Tic Disorder

Tourette Syndrome

STOP-TIC Study: Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT

Similar Clinical Trials

Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Effect of Individualized Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Disorder of Consciousness

Effect of Individualized Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Disorder of Consciousness

The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.

The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.