Evaluation of the Effect of the Implementation of a Candida PCR Diagnosis Strategy on the Time Required to Obtain Results in Patients From Intensive Care Units With Suspected Systemic Invasive Candidiasis: Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in patients from intensive care units with suspected systemic invasive candidiasis. This PCR method could allow an antifungal switch to be made earlier, limiting the appearance of resistance and reducing the cost of antifungals for healthcare facilities.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient affiliated or benefiting from a social protection system

• Patient (or his/her trusted person) having given free and informed written consent to the investigating physician

• Non-neutropenic patient hospitalised in the Toulouse University Hospital intensive care unit.

• Patient with suspected invasive candidiasis for whom a blood culture for fungal infection diagnosis was taken and for whom an empirical treatment with echinocandin at an adapted dose was implemented.

Locations
Other Locations
France
Uh Toulouse
RECRUITING
Toulouse
Contact Information
Primary
Pamela CHAUVIN
chauvin.p@chu-toulouse.fr
05 67 69 04 09
Backup
Xavier IRIART
iriart.x@chu-toulouse.fr
05 67 69 04 99
Time Frame
Start Date: 2022-05-19
Estimated Completion Date: 2025-08-01
Participants
Target number of participants: 120
Treatments
No_intervention: blood culture-based diagnostic strategy
Patients from intensive care units with suspected invasive candidiasis initially treated with echinocandins and who benefited from a blood culture-based diagnostic strategy
Experimental: C. glabrata / krusei PCR diagnostic strategy
Patients from intensive care units with suspected invasive candidiasis initially treated with echinocandins and who benefited from a diagnostic strategy based on C. glabrata / krusei PCR
Sponsors
Leads: University Hospital, Toulouse

This content was sourced from clinicaltrials.gov

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