Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

• Adult patient admitted to an ICU for severe CAP within 48 hours of hospital admission with:

‣ symptoms or signs or both that are consistent with lower respiratory tract infection AND

⁃ Radiological evidence of new onset consolidation (in patients with pre-existing radiological changes, evidence of new infiltrate)

• Up to 48 hours after ICU admission, receiving organ support with one or more of:

‣ Non-invasive or Invasive ventilatory support;

⁃ Receiving infusion of vasopressor or inotropes or both

• Adult patients (≥ 18 years) admitted to hospital with acute illness due to suspected or proven pandemic infection.