Investigation of Cerebellar Involvement in AUD

Status: Recruiting

Location: See location...

Intervention Type: Procedure

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cerebellar, VTA and other brain reward structures? 3. What is the therapeutic potential of cerebellar transcranial direct current stimulation (tDCS) for modulating alcohol cue reactivity, associated alcohol craving, and cerebellar - VTA functional connectivity in the brain reward system? Persons with AUD will be compared with healthy control participants.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 25

Maximum Age: 55

Healthy Volunteers: t

View:

• completed at least 8 years of education

Locations

United States

Maryland

Johns Hopkins University School of Medicine

RECRUITING

Baltimore

Contact Information

Primary

John E Desmond, PhD

jdesmon2@jhmi.edu

410-502-3583

Backup

JoAnna Mathena

Time Frame

Start Date: 2023-10-12

Estimated Completion Date: 2027-09

Participants

Target number of participants: 122

Treatments

Experimental: Cathodal cerebellar transcranial direct current stimulation (ctDCS)

For ctDCS, the cathodal (-) electrode will be positioned over the right cerebellum 1 cm below and 3 cm lateral to the inion, and the anodal (+) electrode will be placed on the contralateral supraorbital area (FP2 EEG location).

Experimental: Anodal cerebellar transcranial direct current stimulation (atDCS)

For atDCS, anode/cathode locations are reversed from those of ctDCS..

Sham_comparator: Sham cerebellar transcranial direct current stimulation (stDCS)

For stDCS, the electrodes will be configured randomly as atDCS 50% of the time, and as ctDCS 50% of the time.

Investigation of Cerebellar Involvement in AUD

Similar Clinical Trials

Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder

Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder