Multicenter Osteoarthritis Study (MOST) Second Renewal
Status: Completed
Location: See all (3) locations...
Study Type: Observational
SUMMARY
The purpose of this study is to investigate opportunities for prevention and treatment of knee osteoarthritis (OA) by evaluating potentially modifiable risk factors for disease and poor pain and physical function outcomes especially among those with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 79
Healthy Volunteers: t
View:
• Age 45 to 69 Years (Adult, Senior)
• Males and Females
• Healthy Volunteers
• Community-based Sample
Locations
United States
Alabama
University of Alabama at Birmingham
Birmingham
Iowa
University of Iowa
Iowa City
Massachusetts
Boston University School of Medicine
Boston
Time Frame
Start Date: 2003-01
Completion Date: 2020-12
Participants
Target number of participants: 4185
Treatments
Early or mild knee symptoms
Existing Cohort study participants (3,026) were enrolled in 2003-2005, Surviving participants without endstage knee osteoarthritis will be asked to participate in the 144-, 152-, 160- and 168-month follow-up contacts \[2,660 were enrolled\].~New Cohort study participants (1,500) will be recruited and enrolled in 2016-2018 \[1,525 were enrolled\].
Authors
James Torner, Cora E. Lewis, Neil Segal
Related Therapeutic Areas
Sponsors
Leads: University of California, San Francisco
Collaborators: University of Iowa, Boston University, National Institute on Aging (NIA), University of Alabama at Birmingham