Phase II Study of Postoperative, Cardiac-Sparing Proton Radiotherapy for Patients With Stage II/III,Loco-Regional, Non-Metastatic Breast Cancer Requiring Whole Breast or Chest Wall Irradiation With Lymph Node Irradiation
The purpose of this study is to look at the rates of acute and long term adverse events of postoperative proton radiotherapy for complex loco-regional irradiation in women with loco-regionally advanced breast cancer. This study specifically includes longitudinal follow up to assess the incidence of cardiac mortality and second malignant neoplasms at 10 and 15 years following proton therapy(PT).
• Must sign study-specific, IRB approved informed consent form prior to study entry. Note consent by legally authorized representative is not allowed for this trial.
• Must be \> = 18 years of age.
• Must have a life expectancy of at least 10 years based on age and comorbidities but excluding diagnosis of breast cancer.
• Must have pathology proven breast cancer. Pathology must be invasive ductal or lobular
• Must meet stage II - III group criteria per AJCC Staging manual 7th edition.
• Must have had surgical treatment of the breast - either mastectomy or breast preserving surgery, such as lumpectomy. Re-excision of surgical margins is permitted.
• Note: Multicentric breast cancer and Paget's disease of the nipple are permitted.