A Prospective, Randomized, Comparative Effectiveness Study of a Single-Use, Negative Pressure Wound Therapy System (PICO) Versus a Traditional Negative Pressure Wound Therapy System (tNPWT) in the Treatment of Lower Extremity Ulcers

• Provide informed consent

• Age ≥ 18 years and of either sex

• Willing to comply with protocol instructions, including allowing all study assessments

• Have a Venous Leg Ulcer (VLU) between the knee and ankle (at or above the malleolus), with a surface area ≥ 2.0 cm2 and ≤ 36.0 cm2

• Target ulcer duration ≥ 4 weeks but ≤ 104 weeks (24 months)

• Have a Diabetic Foot Ulcer (DFU) present on any part of the plantar or dorsum surface of the foot, with a surface area ≥ 0.5 cm2 and ≤ 10.0 cm2

• Target ulcer involves a full thickness skin loss, but WITHOUT exposure of tendon, muscle, or bone

• Target ulcer duration ≥ 4 weeks but ≤ 52 weeks (12 months)

• Acceptable state of health and nutrition