Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA): A Pilot Randomized Controlled Trial and Translational Biology Study
This study is a multi-center, double blind, randomized controlled trial of inhaled nitric oxide (iNO) in children and adults with cardiac arrest (CA). The purpose of this pilot study is to test the feasibility of rapidly randomizing patients to iNO or sham treatment during cardiopulmonary resuscitation (CPR) or shortly after return of circulation (ROC) and evaluate blood biomarkers associated with iNO compared to sham. Return of circulation may refer to return of spontaneous circulation (ROSC) or ROC through extracorporeal cardiopulmonary resuscitation (E-CPR).
⁃ To be eligible to participate in this study, an individual must meet all the following criteria:
• Aged 1 day\* to 80 years on the day the study intervention is started
• In-hospital or out-of-hospital CA with CPR \> 5 minutes
• It is possible to randomize and start the iNO or sham during CPR or within 5 hours of ROC\*\*
• Mechanically ventilated in a study site ICU
⁃ Note: \*Age 1 day is defined as 24 hours and a minimum corrected gestational age ≥ 38 weeks.
⁃ Note: \*\*ROC refers to either ROSC or ROC via extracorporeal cardiopulmonary resuscitation (E-CPR).