Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure (CONNECT-HF)

• Age ≥ 18 years

• Acute HF as a primary cause of hospitalization

‣ Hospitalizations for acute HF will be determined by local clinician-investigators but should include the following:

⁃ Symptoms (eg, dyspnea, fatigue), signs (eg, elevated jugular venous pressure, peripheral edema), or laboratory/imaging evidence of HF (eg, pulmonary congestion on chest x-ray, elevated natriuretic peptide levels) during the hospitalization and

⁃ Treatments aimed at acute HF (eg, intravenous diuretics, vasodilators, or inotropes)

• LVEF ≤ 40% based on last local measurement using echocardiography, multigated acquisition scan, computed tomography (CT) scanning, magnetic resonance imaging, or ventricular angiography

• Planned discharge to home or other supported care facility where patients are individually responsible for medication management