Protective Effects of Propranolol in Adults Following Major Burn Injury: A Safety and Efficacy Trial
Status: Terminated
Location: See all (10) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
This efficacy and safety trial will examine the effects and safety of propranolol administered to adult patients with severe burn injury. The investigators hypothesize that propranolol will provide significant benefit to adults following severe burn injury at doses that are safe and do not increase risk of adverse infectious and non-infectious outcomes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• ≥ 20% Total Body Surface Area (TBSA) burn with anticipated operation need on admission
• Age ≥ 18 years
• Admission within 72 hours of injury
Locations
United States
Florida
University of Florida
Gainesville
Iowa
University of Iowa
Iowa City
Illinois
Loyola University Burn Center
Maywood
Massachusetts
Massachusetts General Hospital
Boston
New York
Cornell Burn Center
New York
Ohio
Ohio State University
Columbus
Texas
University of Texas, Southwestern
Dallas
University of Texas Medical Branch
Galveston
Washington
University of Washington
Seattle
Other Locations
Canada
University of Toronto
Toronto
Time Frame
Start Date: 2013-07
Completion Date: 2019-07-12
Participants
Target number of participants: 47
Treatments
Active_comparator: Propranolol
Propranolol by mouth given daily throughout hospitalization
Placebo_comparator: Sugar Pill
Placebo by mouth given daily throughout hospitalization
Authors
Sponsors
Leads: The University of Texas Medical Branch, Galveston
Collaborators: United States Department of Defense, American Burn Association