Helping Stroke Patients With ThermoSuit Cooling

Status: Terminated
Location: See all (4) locations...
Intervention Type: Drug, Device, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this study is to assess the feasibility of using the Life Recovery Systems ThermoSuit Device to induce therapeutic hypothermia (32-34°C) in victims of ischemic stroke. This feasibility clinical study will enroll a total of 30 patients with acute ischemic stroke at four clinical centers. Subjects will receive hypothermia plus conventional therapy (such as IV-tPA and/or neurothrombectomy therapies if indicated). Endpoints will include feasibility of cooling, adverse events, and neurological recovery in comparison with matched historical controls.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Ischemic cortical stroke with NIHSS \> _5_;

• Treatment must be initiated within 8 hours from known time of symptom onset or, for eligible patients under the current AHA Guidelines, within the extended time window for mechanical thrombectomy of up to 24 hours.

• Patient dimension criteria: Height: 147-190 cm (58 - 75 in) Width: ≤66 cm (26 in) (elbow to elbow).

Locations
United States
Louisiana
Tulane University
New Orleans
Pennsylvania
Geisinger Medical Center
Danville
Geisinger Wyoming Valley Medical Center
Wilkes-barre
South Carolina
U of SC School of Medicine
Columbia
Time Frame
Start Date: 2017-01-25
Completion Date: 2023-06-02
Participants
Target number of participants: 14
Treatments
Experimental: ThermoSuit Cooling Induction
Induction of therapeutic hypothermia (32-34 degrees C) using the LRS ThermoSuit System. Prior to initiating hypothermia, Magnesium Sulfate will be administered intravenously to control shivering and tPA administered intravenously (if indicated). Induction doses of propofol or etomidate will be used to aid in the suppression of patient discomfort. Neurothrombectomy will be performed if indicated.
No_intervention: Historical Control
Historical patients treated for ischemic stroke using conventional medical treatments, but without induced hypothermia.
Related Therapeutic Areas
Sponsors
Collaborators: Geisinger Clinic, Tulane University School of Medicine
Leads: Life Recovery Systems

This content was sourced from clinicaltrials.gov