An Open-Label, Long-Term Safety and Efficacy Evaluation of Diazoxide Choline Extended-Release Tablets in Participants With Prader-Willi Syndrome With a Double-Blind, Placebo-Controlled, Randomized Withdrawal Period

Who is this study for? Children and adults with Prader-Willi syndrome
What treatments are being studied? DCCR
Status: Completed
Location: See all (28) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This is a multi-center, multi-period study with an open-label period followed by a double-blind, placebo-controlled, randomized withdrawal period evaluating the safety and efficacy of DCCR treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 4
Healthy Volunteers: f
View:

• Successful completion of clinical study C601

• Provide voluntary, written informed consent (parent(s) / legal guardian(s) of patient); provide voluntary, written assent (subjects, as appropriate)

• Provide voluntary, written informed consent (parent\[s\] / legal guardian\[s\] of participant); provide voluntary, written assent (participants, as appropriate); this includes consent for randomization and potential treatment with placebo for up to 16 weeks

• Currently participating in clinical study C602 and complete the OLE End of Treatment Visit procedures

Locations
United States
California
University of California, Irvine
Orange
Stanford University
Palo Alto
Rady Children's Hospital San Diego
San Diego
Colorado
Children's Hospital Colorado
Aurora
Florida
University of Florida Gainesville
Gainesville
Georgia
Emory Children's Center
Atlanta
Indiana
Indiana University School of Medicine
Indianapolis
Kansas
Kansas University Medical Center
Kansas City
Massachusetts
Boston Children's Hospital
Boston
Maryland
National Institutes of Health Hatfield Clinical Research Center
Bethesda
Michigan
Sparrow Clinical Research Institute
Lansing
Minnesota
Children's Minnesota
Saint Paul
New Jersey
St. Joseph's University Medical Center
Paterson
New York
NYU Winthrop Hospital
Mineola
Ohio
University Hospitals Cleveland Medical Center
Cleveland
The Research Institute at Nationwide Children's Hospital
Columbus
Tennessee
Vanderbilt University
Nashville
Texas
Research Institute of Dallas
Dallas
Utah
University of Utah
Salt Lake City
Washington
Seattle Children's Hospital
Seattle
Other Locations
United Kingdom
Birmingham Women's and Children's Hospital
Birmingham
Fulbourn Hospital
Cambridge
The Queen Elizabeth University
Glasgow
Hull and East Yorkshire Hospitals NHS Trust
Hull
Aintree University Hospital NHS Foundation Trust
Liverpool
Chelsea and Westminster Hospital
London
Hammersmith Hospital
London
Royal London Hospital
London
Time Frame
Start Date: 2018-10-01
Completion Date: 2023-08-17
Participants
Target number of participants: 115
Treatments
Experimental: OLE DCCR
75 - 525 mg DCCR
Experimental: RW DCCR
75 - 525 mg DCCR
Placebo_comparator: RW Placebo
75 - 525 mg Placebo for DCCR
Related Therapeutic Areas
Sponsors
Leads: Soleno Therapeutics, Inc.

This content was sourced from clinicaltrials.gov

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