Feasibility and Tolerability of the Ketogenic Diet in the Treatment of Refractory Status Epilepticus in a Neurointensive Care Unit.
Status: Completed
Location: See all (9) locations...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This research is being done to observe the safety, tolerability, side effects, and effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus) being treated in a neurointensive care unit.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Patients 18 years and older in refractory status epilepticus (continuous or recurrent seizures without return to baseline mental status between seizures, lasting \> 30 minutes) placed on anesthetics/sedating agents (barbiturates or benzodiazepines) after at least one first- and second-line agent failed to control seizures, and with clinical and/or electrographic seizures following attempt to wean anesthetic/sedating agents after 24 hours.
Locations
United States
Arizona
Mayo Clinic
Phoenix
Hawaii
Queen's Medical Center
Honolulu
Illinois
Rush University Medical Center
Chicago
Maryland
Johns Hopkins University
Baltimore
Minnesota
Mayo Clinic
Rochester
New York
New York University
New York
Oregon
Oregon Health & Science University
Portland
Pennsylvania
Thomas Jefferson University
Philadelphia
Utah
Intermountain Medical Center
Murray
Time Frame
Start Date: 2012-11
Completion Date: 2017-03
Participants
Target number of participants: 15
Treatments
Experimental: Ketogenic diet
Patients will receive the ketogenic diet as a formula delivered via feeding tube. Once able to tolerate food by mouth, patients will be switched to a modified Atkins diet.
Authors
Related Therapeutic Areas
Sponsors
Collaborators: Mayo Clinic, NYU Langone Health, University of Rochester, Queen's Medical Center, Thomas Jefferson University, Oregon Health and Science University, Intermountain Medical Center, Rush University Medical Center
Leads: Johns Hopkins University