Novel Gallium 68 Citrate in Orthopedic Infections
In the proposed study, our aim is to evaluate the uptake of 68Gallium-citrate in patients with failed joint prosthesis and compare it with that of conventional 18fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scan. We will perform PET/CT scan with 68Gallium citrate and 18F-FDG in subjects with failed hip or knee prosthesis. Both 68Gallium-citrate and 18F-FDG scans, done within 24-48 hours from each other, will be performed within 4 weeks before surgical evaluation/revision of the hardware.
• At least 6 months after hip replacement with complaint of joint pain.
• Radiographic studies compatible with prosthesis loosening (i.e. periprosthetic infection or aseptic loosening).
• Pending surgical evaluation and tissue sampling within the next few weeks to differentiate between infection and aseptic loosening.