A Phase IV, 12 Week, Randomised, Double-blind, Double-dummy Study to Compare Single Inhaler Triple Therapy, Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI), With Tiotropium Monotherapy Based on Lung Function and Symptoms in Participants With Chronic Obstructive Pulmonary Disease

• Subjects capable of giving signed informed consent.

• Outpatients will be included in the study.

• Subjects 40 years of age or older at Screening (Visit 1).

• Male or female subjects will be included; a female subject is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies: not a woman of childbearing potential (WOCBP) or a WOCBP who agrees to follow the contraceptive guidance during the treatment period and until the safety follow-up contact after the last dose of study treatment.

• An established clinical history of COPD in accordance with the definition by the American Thoracic Society/European Respiratory Society.

• Current or former cigarette smokers with a history of cigarette smoking of \>=10 pack-years at Screening (Visit 1) (number of pack years = \[number of cigarettes per day / 20\] x number of years smoked \[example given {e.g.}, 20 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years\]). Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1.

• A score of \>=10 on the COPD Assessment Test (CAT) at Screening (Visit 1).

• Subjects must demonstrate at Screening: A post-bronchodilator FEV1 \<50 percent predicted normal or a post-bronchodilator FEV1 \<80 percent predicted normal and a documented history of \>=2 moderate exacerbations or one severe (hospitalized) exacerbation in the previous 12 months. Subjects must also have a measured post albuterol/salbutamol FEV1/forced vital capacity (FVC) ratio of \<0.70 at screening.

• Subjects must have been receiving daily maintenance treatment with tiotropium alone (via the HANDIHALER or RESPIMAT®) for their COPD for at least 3 months prior to Screening.