Hydroxytyrosol Bioavailability in Humans: a Comparative Study of Three EPA-Enriched Formulations
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The primary objective of this study is to evaluate the optimal formulation of a natural nutraceutical whose daily consumption at nutritional doses may confer benefits for cardiovascular health. This nutraceutical combines an omega-3 fatty acid (eicosapentaenoic acid, EPA) with hydroxytyrosol (a potent antioxidant found in olives and extra virgin olive oil). The study will allow to compare how and to what extent hydroxytyrosol is absorbed when co-administered the omega-3 fatty acid in capsules across three different formulations.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:
• Age: 18 to 45 years old
• Body Mass Index (BMI): 18 to 25 kg/m²
Locations
Other Locations
Spain
Ictan-Csic
RECRUITING
Madrid
Contact Information
Primary
Raquel Mateos Briz Tenured Scientist
raquel.mateos@ictan.csic.es
+34915492300
Backup
Marta Jordán Romero Predoctoral Researcher
mjordan@ictan.csic.es
+34915492300
Time Frame
Start Date: 2024-11-18
Estimated Completion Date: 2025-01
Participants
Target number of participants: 12
Treatments
Experimental: HT-Ac → HT-EPA → Oleacore®
Group 1 will consume HT-Ac in the first week, HT-EPA in the second week and Oleacore® in the third week.
Experimental: HT-EPA → Oleacore® → HT-Ac
Group 2 will consume HT-EPA in the first week, Oleacore® in the second week and HT-Ac in the third week.
Experimental: Oleacore® → HT-Ac → HT-EPA
Group 3 will consume Oleacore® in the first week, HT-Ac in the second week and HT-EPA in the third week.
Sponsors
Leads: National Research Council, Spain
Collaborators: Olivenova Health Sl