4D Phase Contrast MR: Validation and Evaluation of Hypertrophy in Liver Cancer

Status: Terminated
Location: See location...
Intervention Type: Procedure, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The investigators hypothesize that 4Dimensional Phase Contrast Magnetic Resonance Angiography (4D PC MRA) evaluation of portal venous flow predicts underlying liver function and hypertrophic potential in patients with liver cancer presenting for portal vein embolization (PVE). 4D PC MRA may provide a non-invasive measure of liver function that could help determine which patients could safely and successfully undergo PVE and subsequent resection of tumor. By comparing 4D PC MRA results with invasive catheter measurements the investigators will validate the flow findings. Further regression/correlation analysis with functional measures of the liver (HIDA scans), volumetrics, Doppler flow analysis, histology, and outcomes will help the investigators to determine the ability of 4D PC MRA to predict functional status and hypertrophic potential of the liver prior to PVE and hepatectomy allowing for better patient selection and reduced morbidity/mortality.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosis of malignant liver tumor

• Clinically referred for portal vein embolization

• At least 18 years of age

• Willing and able to provide informed consent

Locations
United States
Missouri
Washington University School of Medicine
St. Louis
Time Frame
Start Date: 2014-08-05
Completion Date: 2016-02-04
Participants
Target number of participants: 10
Treatments
Experimental: Arm 1: 4D phase contrast MR scan
* Each patient will undergo a total of 3 MRI/MRA scans (lasting 30-60 minutes):~ * Scan 1: Baseline (pre-portal vein embolization (PRE))~ * Scan 2: Early after PVE (within 48 hours)~ * Scan 3: Late after PVE (at 3-8 weeks).~* Scans 1 and 3: routine liver MR sequences with/without contrast (Gadoxetic acid, Eovist) and 4D phase contrast of the portal venous system. The 4D phase contrast sequence will be repeated twice at each time point, adding about 15-30 minutes to each scan.~* Scan 2: 4D phase contrast sequences and imaging for localization.
Related Therapeutic Areas
Sponsors
Leads: Washington University School of Medicine

This content was sourced from clinicaltrials.gov

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