Aldosterone and Sodium Regulation in Postural Tachycardia Syndrome - Screening Protocol

Status: Active_not_recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of the study is to determine whether patients meet criteria for Postural Tachycardia Syndrome (or not) and have reduced blood volume (or not). Both of these are important screening elements to Aim 3 of a National Institutes of Health Grant. The purposes of Aim 3 are to determine 1. whether a high dietary sodium level appropriately expands plasma volume in Postural Orthostatic Tachycardia, 2. whether plasma renin activity and aldosterone are modified appropriately by changes in dietary sodium in Postural Tachycardia Syndrome and 3. whether patients with Postural Tachycardia Syndrome have improvements in their orthostatic tachycardia and symptoms as a result of a high dietary sodium level.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• Age between 18-50 years old

• Patients with suspected POTS and healthy volunteers

• Sedentary healthy subjects of similar age and gender than patients will also be recruited.

• Only female participants are eligible.

• Able and willing to provide informed consent

Locations
United States
Tennessee
Vanderbilt University Medical Center
Nashville
Time Frame
Start Date: 2013-02
Completion Date: 2025-12
Participants
Target number of participants: 110
Treatments
Other: All participants
All participants will be administered all procedures as described previously.~Interventions:~Autonomic Function Testing, Posture Study ,Measurement of Total Blood Volume ,Exercise Capacity Test
Authors
Emily Garland, Satish Raj
Sponsors
Leads: Vanderbilt University
Collaborators: National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)

This content was sourced from clinicaltrials.gov

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