Combined Breast MRI/Biomarker Strategies to Identify Aggressive Biology
Status: Active_not_recruiting
Location: See all (5) locations...
Intervention Type: Procedure, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This clinical trial studies normal breast tissue changes combined with breast magnetic resonance imaging (MRI) that may suggest the beginnings of cancer development. Using breast tissue markers in combination with breast imaging such as MRI may help to more accurately assess a woman's risk of developing breast cancer.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: t
View:
• Women who are undergoing screening breast MRI as per standard of care for high-risk breast cancer screening
• Willing to donate left-over tissue if patient undergoes a breast biopsy and/or breast surgery
• Willing to have about 40 mL of blood (approximately 3 tablespoons) drawn
• Documented informed consent of the participant
Locations
United States
California
City of Hope Medical Center
Duarte
University of Southern California
Los Angeles
North Carolina
Duke University
Durham
Ohio
Ohio State University, Stefanie Spielman Comprehensive Breast Center
Columbus
Wisconsin
University of Wisconsin
Madison
Time Frame
Start Date: 2017-10-13
Completion Date: 2026-04-25
Participants
Target number of participants: 344
Treatments
Experimental: Treatment (breast MRI, biopsy)
Participants undergo standard of care high risk breast cancer screening MRIs at baseline and follow-up and blood sample collection at baseline. Participants also undergo collection of breast tissue samples at any breast biopsy or breast surgery.
Authors
Related Therapeutic Areas
Sponsors
Leads: City of Hope Medical Center
Collaborators: National Cancer Institute (NCI)