A Phase 2, Open-label, Multicenter, Study of an Immunotherapeutic Treatment, DPX-Survivac in Combination With Low Dose Cyclophosphamide and Pembrolizumab, in Subjects With Selected Advanced and Recurrent Solid Tumours.
This study will assess the safety and efficacy of DPX-Survivac and low dose cyclophosphamide with pembrolizumab in subjects with selected advanced and recurrent solid tumours.
• Subjects with advanced or metastatic solid tumours who have completed treatment with first line therapy:
‣ Epithelial ovarian, fallopian tube, or peritoneal cancer
⁃ Hepatocellular carcinoma
⁃ Non-small cell lung cancer
⁃ Urothelial cancer
⁃ Microsatellite instability high solid tumours, other than the above indications
• Radiologic and/or biochemical evidence of disease progression
• Completion of pre-treatment tumour biopsy
• Must have measurable disease by RECIST v1.1
• Ambulatory with an ECOG 0-1
• Life expectancy ≥ 6 months
• Meet protocol-specified laboratory requirements