Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
Status: Active_not_recruiting
Location: See all (20) locations...
Study Type: Observational
SUMMARY
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 80
Healthy Volunteers: t
View:
• At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled)
• Self-designation of non-Hispanic white or African-American
Locations
United States
Alabama
University of Alabama at Birmingham
Birmingham
California
University of California at San Diego
San Diego
Los Angeles Biomedical Research Institute
Torrance
Colorado
National Jewish Health
Denver
Georgia
Morehouse School of Medicine
Atlanta
Iowa
University of Iowa
Iowa City
Massachusetts
Brigham and Women's Hospital
Boston
Reliant Medical Group
Worcester
Maryland
Johns Hopkins University
Baltimore
Michigan
Ann Arbor VA Medical Center
Ann Arbor
University of Michigan
Ann Arbor
Minnesota
HealthPartners Research Foundation
Minneapolis
Minneapolis VA Medical Center
Minneapolis
University of Minnesota
Minneapolis
North Carolina
Duke University
Durham
New York
Columbia University Medical Center
New York
Pennsylvania
Temple University
Philadelphia
University of Pittsburgh
Pittsburgh
Texas
Baylor College of Medicine
Houston
University of Texas Health Sciences Center at San Antonio
San Antonio
Time Frame
Start Date: 2007-11
Completion Date: 2028-08
Participants
Target number of participants: 10718
Treatments
NHW COPD Participants
Non-Hispanic white participants with COPD
NHW Control Group
Non-Hispanic white participants with normal spirometry (do not have COPD)
AA COPD Participants
African-American participants with COPD
AA Control Group
African-American participants with normal spirometry (do not have COPD)
Authors
Related Therapeutic Areas
Sponsors
Leads: Brigham and Women's Hospital
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)