Feasibility Study: Therapeutic Targeting of Stress Factors in Ovarian Cancer Patients
This early phase I trial studies giving propranolol hydrochloride with standard chemotherapy in treating patients with ovarian, primary peritoneal, or fallopian tube cancer. Biological therapies, such as propranolol hydrochloride, blocks certain chemicals that affect the heart and this may stimulate the immune system and allow the chemotherapy to kill more tumor cells.
• Suspected preoperative diagnosis of invasive epithelial ovarian cancer, primary peritoneal carcinoma, fallopian tube cancer based on imaging and cancer antigen (Ca) 125; histologic epithelial cell types are eligible: serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell carcinoma, mixed epithelial carcinoma, or adenocarcinoma not otherwise specified; patients with primarily carcinoma histology but mixed features can be included; the surgically confirmed histologic features must be compatible with primary Mullerian epithelial adenocarcinoma
• Stages II-IV of the above cancer
• Patients to be scheduled for a planned tumor debulking
• Intention for chemotherapy administration at MD Anderson Cancer Center
• Zubrod performance status 0-2
• Absolute neutrophil count (ANC) \>= 1500/ml
• Platelets \> 100,000/mL
• Creatinine clearance (CrCl) \> 50 mL/min
• Bilirubin =\< 1.5 x institutional upper limit normal
• Serum glutamic oxaloacetic transaminase (SGOT) =\< 2.5 x institutional upper limit normal
• Alkaline phosphatase =\< 2.5 x institutional upper limit normal
• Neuropathy (sensory and motor) =\< grade 1 according to Common Toxicity Criteria for Adverse Events version 3 (CTCAE)
• Prothrombin time (PT) such that international normalized ratio (INR) is =\< 1.5 (or an in-range INR, usually between 2 and 3, if a patient is on a stable dose of therapeutic warfarin for the management of venous thrombosis including pulmonary embolus)
• Partial thromboplastin time (PTT) \< 1.2 times institutional upper limit of normal
• Pulse \>= 60 beat per minute (bpm)
• Systolic blood pressure (SBP) \> 110 mmHg; diastolic blood pressure (DBP) \>= 60 mmHg
• Normotensive individuals not already on beta blockers (may be on other anti hypertensives): SBP =\< 140, DBP =\< 90
• Surgery or neoadjuvant chemotherapy must be scheduled at least 72 hours in advance in order for the patient to take at least 48 hours of prescribed propranolol and have stable vital signs confirmed
• An approved informed consent and authorization permitting release of personal health information must be signed by patient or guardian
• Patients of childbearing age must have a negative pregnancy test
• Patients who receive neoadjuvant chemotherapy for their ovarian, primary peritoneal, or fallopian tube cancer