Obesity & Asthma: Nutrigenetic Response to Omega-3 Fatty Acids
Status: Completed
Location: See all (3) locations...
Intervention Type: Dietary supplement, Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
This project will assess the effectiveness of omega-3 fatty acid supplementation in controlling asthma symptoms among obese asthmatics, and will assess if a person's genes influence response to treatment (personalized medicine). This project may improve our ability to treat asthma and our understanding of the link between obesity and asthma.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 25
Healthy Volunteers: f
View:
• age 12-25
• BMI \> 25 (age 18-25) or BMI%\>85th (age 12-17) (BMI Liberalized)
• Physician diagnosis of persistent asthma
• Lung function responsiveness by bronchodilator reversibility or bronchoprovocation testing
Locations
United States
Florida
Nemours Children's Clinic
Jacksonville
Nemours Children's Hospital/Dept of Pulmonology
Orlando
University of South Florida, Morsani College of Medicine
Tampa
Time Frame
Start Date: 2010-07
Completion Date: 2016-10-22
Participants
Target number of participants: 143
Treatments
Experimental: omega-3 fatty acids
3 softgels (EPA, DHA) twice daily
Placebo_comparator: control
Soybean oil: 3 matched softgel caps twice daily
Authors
John J Lima, Thomas B. Casale
Sponsors
Collaborators: Office of Dietary Supplements (ODS), National Heart, Lung, and Blood Institute (NHLBI)
Leads: Nemours Children's Clinic