Effect of Nitric Oxide (NO) Supplementation on Neurocognitive Measures in Argininosuccinate Lyase Deficiency (ASLD)
This is a study involving a dietary supplement. Patients with argininosuccinate lyase deficiency (ASLD) will be randomly assigned to receive either a nitric oxide dietary supplement or placebo for 24 weeks, and then crossed-over to receive the other treatment for 24 weeks. The investigators will assess the effects of the supplement in domains of general cognition, memory, executive functioning, and fine motor functioning in individuals with ASLD.
• Age \> 6 and \<50 years
• Diagnosis of ASLD confirmed by biochemical OR enzymatic OR genetic testing
• Has a history of compliance with diet and treatment
• Negative pregnancy test and ability to use birth control method for the entire duration of the study (if the subject is of child-bearing potential)
• Males who enroll in the study (and their partners) should argee to use an acceptable form of birth control for the entire duration of the study