The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke
The primary objective of the trial is to establish the effectiveness of IAT (versus medical management) in patients with moderate-large infarcts (NCCT ASPECTS 2-5) at baseline, with adaptive enrichment to better define the upper limit of infarct volume for treatment eligibility. Furthermore, the investigators aim to determine whether certain subgroups of patients with large baseline infarcts will have a greater treatment benefit. Finally, the investigators will assess the agreement of ASPECTS scores between site investigators, the core imaging lab, and automated software.
• 18 to 85 years of age
• Presenting with symptoms consistent with an acute ischemic stroke
• Imaging evidence of an anterior circulation occlusion of the Internal Carotid Artery (ICA) terminus and/or Middle Cerebral Artery Main Stem (MCA M1) segment
• NIHSS score \>6 at the time of randomization
• Ability to randomize within 24 hours of stroke onset
• Pre-stroke mRS score 0-1
• Ability to obtain signed informed consent
⁃ Imaging evidence of moderate-large infarct defined as:
• NCCT ASPECTS 2-5