Open Label 8-Week Study of Prazosin Use in Adults With Anxiety Disorders

Who is this study for? Adult patients with Anxiety
What treatments are being studied? Prazosin
Status: Suspended
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

Prazosin has shown effectiveness in treating Post-Traumatic Stress Disorder through improving sleep quality and global functioning. Given the significant evidence for its utility in treating PTSD, in combination with the fact that many anxiety symptoms overlap with PTSD (e.g.insomnia, hyperarousal, and irritability), it is essential to evaluate its potential effectiveness in treating symptoms of other anxiety disorder and patient tolerability.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• Existing Diagnosis of any anxiety disorder according to DSM-5 criteria (i.e. GAD, Panic Disorder, Agoraphobia, Social Phobia or Specific phobias)

• Newly diagnosed patients or patients who are either resistant or not adherent to their current treatment are eligible to be enrolled in the study.

• If patient is on anti-hypertensive therapy, the dose of anti-hypertensive(s) must be stable for at least 4 weeks prior to the study and blood pressure must be well controlled.

Locations
Other Locations
Canada
University of Manitoba - PsycHealth - Mood and Anxiety Disorders Clinic
Winnipeg
Time Frame
Start Date: 2019-05-24
Completion Date: 2023-12
Participants
Target number of participants: 20
Treatments
Experimental: Open-label treatment with Prazosin
Week 1 Day 1-3: 0.5 mg at bedtime Day 4-7: 1.0 mg at bedtime Week 2 Day 8-10: 2.0 mg at bedtime Day 11-14: 4.0 mg at bedtime Week 3 2 mg in the morning, 4 mg at bedtime Week 4 4 mg in the morning, 4 mg at bedtime Week 5 4 mg in the morning, 6 mg at bedtime Week 6 4 mg in the morning, 8 mg at bedtime~Dosage of Prazosin will be titrated at the discretion of the study physician.
Sponsors
Leads: University of Manitoba

This content was sourced from clinicaltrials.gov