The Organ Care System (OCS™) Lung Thoracic Organ Perfusion (TOP) Registry for Donor Lungs for Transplantation

Status: Active_not_recruiting
Location: See all (18) locations...
Intervention Type: Device
Study Type: Observational
SUMMARY

Single-arm, prospective, multi-center, post-approval U.S. registry

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

⁃ This is an all-comers registry that will enroll all:

• Patients who receive OCS™ preserved double lung transplants from either standard criteria donors or donors initially deemed unacceptable; and

• Patients who receive a single lung transplant from OCS™ preserved lung pairs from either standard criteria donors or donors initially deemed unacceptable; and

• All donor lungs that were perfused on OCS Lung System.

⁃ Enrolled patients will fall into one of the following three possible analysis categories:

• TOP SCDL PAS Primary Analysis Population: will be comprised of recipients transplanted with SCDL primary analysis population eligible donor lungs preserved on the OCS™ Lung System.

• TOP DLIDU Primary Analysis Population: Will be comprised of recipients transplanted with DLIDU primary analysis population eligible donor lungs preserved on the OCS™ Lung System.

• All Other Enrolled Patients: will be comprised of all OCS Lung transplanted patients in the TOP Registry that do not meet any of the above analysis populations.

Locations
United States
Arizona
St. Joseph's Hospital and Medical Center
Phoenix
California
UCLA
Los Angeles
Stanford University
Palo Alto
UCSF
San Francisco
Florida
Tampa General Hospital
Tampa
Georgia
Emory
Atlanta
Illinois
University of Chicago
Chicago
Massachusetts
Massachusetts General Hospital
Boston
Maryland
Johns Hopkins
Baltimore
Michigan
Henry Ford Health System
Detroit
Minnesota
University of Minnesota
Minneapolis
North Carolina
Duke University
Durham
Nebraska
Nebraska Medical Center
Omaha
Pennsylvania
Temple University
Philadelphia
Texas
Baylor Scott & White Research Institute
Dallas
Baylor St. Luke's Medical Center
Houston
Houston Methodist
Houston
Wisconsin
Medical College of Wisconsin
Milwaukee
Time Frame
Start Date: 2018-12-10
Completion Date: 2029-11-30
Participants
Target number of participants: 458
Treatments
Standard Donor Lungs Primary Analysis Population
Recipients transplanted with primary analysis population eligible donor lungs preserved on the OCS™ Lung System.
Donor Lungs Initially Unacceptable Primary Analysis Pop.
Recipients transplanted with primary analysis population eligible donor lungs preserved on the OCS™ Lung System.
All Other Enrolled Patients
All OCS Lung transplanted patients that do not meet any of the above analysis populations.
Related Therapeutic Areas
Sponsors
Leads: TransMedics

This content was sourced from clinicaltrials.gov

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