The Effects of a High Intensity Exercise Training Program on Sleep and Vigilance in Patients With Parkinson's Disease (The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients)
The purpose of this randomized, controlled interventional study is to determine the effects of a high intensity exercise training program on objective sleep measures, daytime sleepiness, mobility, and brain health/functional connectivity in patients with Parkinson's disease.
• Subjects with a clinical diagnosis of idiopathic Parkinson's disease based on the presence of bradykinesia and one or both of the following: rest tremor and/or rigidity
• Hoehn and Yahr stage 2 or 3
• Stable dopaminergic medication regimen for at least 4 weeks prior to study entry without anticipation of medication change for the duration of the study.
• Stable doses of medications known to affect sleep and medications for Parkinson's disease for at least 4 weeks prior to study entry without anticipation of medication change for the duration of the study.
• Age 45 or greater at time of study entry
• Asymmetric onset of PD
• Progressive motor symptoms of PD
• Poor sleep quality (Pittsburgh Sleep Quality Index score \>5)
• MoCA score 18-26
⁃ Ability to travel to UAB 3x/week for the 16 weeks duration of the study for exercise training sessions as well as for other study visits
⁃ Subjects must pass a physical examination and PAR-Q to assess exercise readiness
• Age 45 or greater at time of study entry
• Poor sleep quality (Pittsburgh Sleep Quality Index score \>5)
• Normal cognition