Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children.
Journal: Biomarkers : Biochemical Indicators Of Exposure, Response, And Susceptibility To Chemicals
Published:
Abstract
Objective: To find the best lead exposure assessment marker for children.
Methods: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level.
Results: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score.
Conclusions: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
Authors
Linda Nie, Robert Wright, David Bellinger, Javed Hussain, Chitra Amarasiriwardena, David Chettle, Ana Pejović Milić, Alan Woolf, Michael Shannon
Relevant Conditions