• Male or female subjects between 18 and 75 years of age.

• Clinical diagnosis of chronic atopic dermatitis (also known as atopic eczema) for at least 1 year

• Documented recent history of inadequate response to TCS or TCI, or for whom topical treatments are otherwise medically inadvisable.

• Subjects must meet the following criteria for disease activity:

‣ Eczema Area and Severity Index (EASI) score ≥ 16 ;

⁃ (Body Surface Area )BSA affected by AD ≥ 10% ;

⁃ (validated Investigator's Global Assessment-AD)vIGA-AD score ≥3 ;

⁃ Baseline weekly average of daily Worst Pruritus NRS ≥ 4.

• Women of childbearing potential (WOCBP) and Men must agree

• Women of childbearing potential (WOCBP) and Men must agree to contraception. 6. Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.