Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)
Status: Terminated
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal is to characterize vascular reactivity and cardiac pulsatility of normal appearing white matter in patients with CCM during hypercarbia/hypocarbia using quantitative real-time high-speed multi-echo fMRI to develop prognostic biomarkers for CCM formation
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• All familial CCM subjects presenting at UNMH who can consent to our study.
• Adult Male/Female patients ages \>18 years old
Locations
United States
New Mexico
University of New Mexico Neurology Research Center
Albuquerque
Time Frame
Start Date: 2023-06-15
Completion Date: 2024-07-17
Participants
Target number of participants: 5
Treatments
Experimental: Hypercarbia/Hypocarbia/resting state during fMRI
During real time fMRI, all subjects will completed breathing tasks though a mask that supplies gas mixtures using the RespirAct™ Gas Control System (Thornhill Medical). The RespirAct™ is a computer-controlled gas blender providing carbon dioxide (CO2), oxygen (O2) and nitrogen for a subject to inhale while breathing for the purpose of controlling the concentrations of the respective blood gases.~For hypocarbia, subjects will be instructed to pace their breathing to 16- 20 breaths-per-minute to achieve a stable target end-tidal CO2 between 30 and 40 mm Hg.~Hypercarbia will be induced by increasing CO2 concentration and flow rate of the gas mixture until a desired ETCO2 level between 40 and 50 mm Hg has been reached.~There will also be a 10 minutes rest period during which respiratory rate and heart rate will be monitored continuously.
Related Therapeutic Areas
Sponsors
Leads: University of New Mexico
Collaborators: University of California, San Francisco