Biomarker Profiling in Individuals at Risk for Prion Disease
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the direction of future clinical trials.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:
• Aged 18 - 85,
• One of the following:
‣ Known carrier of pathogenic PRNP mutation
⁃ History of probable or definite prion disease in biological parent and other family members
• Medically safe to undergo blood draw, lumbar puncture and cognitive testing,
• Adequate visual and auditory acuity to complete cognitive testing,
• Fluent in English,
• At least 5 years of education,
• Capable of providing informed consent and following study procedures.
Locations
United States
Massachusetts
Alzheimer's Clinical and Translational Research Unit
RECRUITING
Charlestown
Contact Information
Primary
Davi Soares
dsoares3@mgh.harvard.edu
617-724-6094
Backup
Jess Gerber
jgerber2@mgh.harvard.edu
Time Frame
Start Date: 2017-12-01
Estimated Completion Date: 2025-06-01
Participants
Target number of participants: 80
Treatments
Individuals with a family history of Prion disease
Individuals with a family history of Prion disease
Related Therapeutic Areas
Sponsors
Collaborators: Broad Institute of MIT and Harvard
Leads: Massachusetts General Hospital