A Randomised Double-blind Placebo-controlled Clinical Trial Investigating the Effect and Safety of Oral Semaglutide in Subjects With Early Alzheimer´s Disease (EVOKE Plus)
Who is this study for? Patients with early Alzheimer's disease
What treatments are being studied? Semaglutide
Status: Active_not_recruiting
Location: See all (478) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a dummy medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken. Participants must have a study partner, who is willing to take part in the study. Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period. A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Maximum Age: 85
Healthy Volunteers: f
View:
• Male or female, aged 55-85 years (both inclusive) at the time of signing informed consent.
• MCI (mild cognitive impairment) or mild dementia of the Alzheimer's type according to the NIA-AA (National Institute of Aging-Alzheimer's Association) 2018 criteria.
• CDR (Clinical Dementia Rating) global score of 0.5 and CDR of 0.5 or more in at least one of the three instrumental activities of daily living categories (personal care, home \& hobbies, community affairs) Or CDR global score of 1.0
• RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) delayed memory index score of below or equal to (≤) 85
• MMSE (Mini-Mental State Examination) greater than or equal to (≥) 22
• Amyloid positivity established with either amyloid PET (positron emission tomography), CSF (cerebrospinal fluid) Aβ1-42 or CSF Aβ1-42/Aβ1-40.
• If receiving an approved Alzheimer's disease treatment (such as acetylcholinesterase inhibitors, memantine or aducanumab) the dose must have been stable for at least 3 months prior to screening and should not be changed during the study unless medically necessary.
Locations
United States
Arizona
Banner Alzheimer's Institute
Phoenix
Imaging Endpoints
Scottsdale
Banner Sun Health Research Institute
Sun City
Tucson Neuroscience Research
Tucson
California
Advanced Research Center, Inc.
Anaheim
Torrance Clin Res Inst, Inc.
Lomita
ASCLEPES Research Centers,
Long Beach
Cedars-Sinai Medical Center
Los Angeles
UCLA_Los Angeles
Los Angeles
Wr-Pri, Llc
Newport Beach
Well Care Medical Center
Panorama City
Cedars-Sinai Medical Center
Pasadena
Sharp Neurocog Res Ctr
San Diego
Syrentis Clinical Research
Santa Ana
Calfornia Neurosc Resrch Med
Sherman Oaks
Southern California Research LLC
Simi Valley
Colorado
Mountain Neurological Research Center, Inc.
Basalt
Denver Neurological Research
Denver
Mile High Research Center
Denver
Connecticut
Nuvance Health, Associtd Neuro
Danbury
Yale University
Fairfield
Research Center for Clinical Studies, Inc
Norwalk
Florida
Topaz Clinical Research
Apopka
JEM Research Institute
Atlantis
Visionary Investigators Network
Aventura
K2 Medical Research - Winter Garden
Clermont
Brain Matters Research
Delray Beach
Integrity Clinical Research, LLC
Doral
Neuropsychiatric Research Cent
Fort Myers
Finlay Medical Research Group
Greenacres City
Galiz Research
Hialeah
Hlth Cr Family Rehab & Res Ctr
Hialeah
Indago Research & Health Center Inc.
Hialeah
K2 The Villages
Lady Lake
K2 Medical Research, Maitland
Maitland
Central Miami Medical Institute
Miami
Hlth Cr Family Rehab & Res Ctr
Miami
IMIC, Inc- Medical Research
Miami
Novel Clinical Research Center, LLC
Miami
Premier Clin Res Inst, Inc.
Miami
Premier Clinical Research Institute, Inc.
Miami
The Neurology Research Group
Miami
Visionary Inv Ntwrk_Miami
Miami
Aqualane Clinical Research
Naples
Suncoast Clin Res Port Richey
New Port Richey
Suncoast Clinical Research, Inc._New Port Richey
New Port Richey
K2 Medical Research - Winter Garden
Ocoee
Combined Research Orlando Phase I-IV
Orlando
Headlands Research Orlando
Orlando
Advanced Research Consultants, Inc.
Palm Beach Gardens
Intercoastal Medical Group
Sarasota
The Roskamp Institute, Inc.
Sarasota
Brain Matters Resrch Kane Cntr
Stuart
Axiom Clinical Research of Florida
Tampa
Stedman Clinical Trials LLC
Tampa
Palm Beach Neuro Premiere Res
West Palm Beach
Conquest Research
Winter Park
Georgia
iResearch Atlanta, LLC
Decatur
Hawaii
Hawaii Neuroscience, Memory Disorders Center
Honolulu
Idaho
Velocity Clinical Research
Meridian
Velocity Clinical Research, Meridian
Meridian
Indiana
Josephson Wallack Munshower
Indianapolis
Kansas
Cotton-O'Neil Clinical Research Center
Topeka
Kentucky
University of Kentucky_Lexington_0
Lexington
Massachusetts
ActivMed Practice & Research LLC
Methuen
Maine
Northern Light Eastern Maine Medical Center
Bangor
Michigan
Bronson Lakeview Neurobehavioral Health
Paw Paw
Minnesota
HealthPartners Center for Memory and Aging
Saint Paul
Mississippi
Hattiesburg Clinic
Hattiesburg
North Carolina
New Hope Clinical Research
Charlotte
AMC Research, LLC
Matthews
New Jersey
Patient First MD,clinical Trials
Middletown
Advanced Memory Research Institute of NJ
Toms River
New Mexico
Albuquerque neuroscience Inc
Albuquerque
Nevada
Altea Research Institute
Las Vegas
Wr-Crcn, Llc
Las Vegas
New York
SPRI Clinical Trials, LLC
Brooklyn
Neurological Assoc Long Island
Lake Success
Feinstein Institute for Medical Research
Manhasset
NYU Grossman School of Med
New York
Richmond Behavioral Associates
Staten Island
SUNY Upstate Medical University_Syracuse
Syracuse
Ohio
NeuroScience Research Center, LLC
Canton
Valley Medical Primary Care
Centerville
Insight Clinical Trials LLC
Independence
Cleveland Clinic_Lakewood
Lakewood
Oklahoma
Central States Research, LLC
Tulsa
Oregon
Neural Net Research, LLC
Portland
Summit Research Network Oregon Inc.
Portland
Pennsylvania
The Clinical Trial Center
Jenkintown
Suburban Research Associates
Media
South Carolina
Lowcountry Center for Vet Res
Charleston
Coastal Neurology
Port Royal
Palmetto Clinical Research
Summerville
Tennessee
Genesis Neuroscience Clinic
Knoxville
Vanderbilt Medical Center
Nashville
Texas
Texas Diabetes & Endocrinology
Austin
Neurology Consultants of Dallas
Dallas
Balyor College of Medicine
Houston
Univ Of Texas Hlth Science Cntr
Houston
Mt. Olympus Medical Research
Katy
Glenn Biggs Inst-Alzhm Neuro
San Antonio
Shirzadi Shahin, MD
Sugar Land
Virginia
Integrated Neurology Services
Falls Church
Vermont
Memory Clinic, Inc
Bennington
Washington
Booth Gardner Parkinson's Cre
Kirkland
Harborview Medical Center
Seattle
Other Locations
Argentina
Hospital Italiano
Buenos Aires
Instituto de Investigaciones Metabolicas (IDIM)
Buenos Aires
Clínica Nuestra Señora de las Nieves
Caba
FLENI
Caba
Instituto Medico Especializado_Capital Federal
Ciudad De Buenos Aires
Instituto Privado Kremer
Córdoba
Fundación Scherbovsky
Mendoza
Australia
The Prince Charles Hospital
Chermside
St Vincent's Hospital
Darlinghurst
HammondCare Greenwich
Greenwich
Medical and Cognitive Research Unit - Austin Health
Ivanhoe
Southern Neurology
Kogarah
KaRa Institute of Neurological Disease Pty Ltd
Macquarie Park
HammondCare
Malvern
Alzheimer's Research Australia
Nedlands
Australian Alzheimer's Research Foundation Incorporated
Nedlands
Hunter New England Local Health District - Neuropsychiatry
Waratah
Austria
Universitätsklinik für Neurologie
Graz
LKH-Univ. Kliniken Innsbruck
Innsbruck
Medizinische Univ. Innsbruck
Innsbruck
Univ. Klinik für Neurologie
Salzburg
Medizinische Universität Wien
Vienna
Belgium
AZ Sint-Jan - Campus Sint-Jan - Neurology
Bruges
UZA - UZ Antwerpen - Department of Neurology
Edegem
UZ Gent - Neurologie
Ghent
AZ Groeninge - Kortrijk - Neurologie
Kortrijk
UZ Leuven - Geheugenkliniek
Leuven
Clinique CHC MontLégia - Service Neurologie
Liège
Brazil
Hospital das Clínicas - Universidade Federal de Minas Gerais
Belo Horizonte
L2 IP Instituto de Pesquisas Clinicas Ltda
Brasília
Instituto de Neurologia de Curitiba
Curitiba
Clinica Clinilive Ltda
Maringá
Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.
Porto Alegre
Centro de Psiquiatria Sandra Rushel
Rio De Janeiro
Assoc. Paulista para o Desenvolvimento da Medicina - UNIFESP
São Paulo
BR Trials - Ensaios Clínicos e Consultoria Ltda.
São Paulo
CPQuali Pesquisa Clínica Ltda
São Paulo
Sociedade Beneficente Israelita Bras Hosp Albert Einstein
São Paulo
Bulgaria
DCC Sv. Vrach and Sv. Sv. Kuzma and Damyan OOD, Psychiatry
Sofia
MHATNP Sv. Naum EAD
Sofia
MHATNP Sveti Naum EAD
Sofia
MMA, MHAT-Sofia, Neurology clinic
Sofia
UMHAT Aleksandrovska, Neurology clinic
Sofia
Canada
MoCA Research Innovation Inc
Greenfield Park
True North Clinical Research - Halifax
Halifax
OCT Research ULC (dba Okanagan Clinical Trials)
Kelowna
Douglas Hosp Res Ctr
Montreal
True North Clinical Research - New Minas
New Minas
Medical Arts Health Research Group
North Vancouver
Ottawa Memory Clinic
Ottawa
Recherches Neuro-Hippocampe Inc
Ottowa
Medical Arts Health Research Group_Kelowna
Penticton
Kawartha Centre Redefining Healthy Aging
Peterborough
CHU de Quebec-Universite Laval
Québec
Diex Recherche Sherbrooke Inc.
Sherbrooke
Centricity Research LMC
Toronto
Memory Program
Toronto
St. Michael's Hospital
Toronto
St. Michael's Hospital
Toronto
Sunnybrook Health Sciences Centre
Toronto
University Health Network
Toronto
Island Health (Research and Capacity Building)
Victoria
China
Baogang Hospital of Inner Mongolia-Neurology
Baotou
Beijing Anding Hospital Capital Medical University-Geriatric Psychiatry
Beijing
Beijing Chao-Yang Hospital, Capital Medical University-Neuro
Beijing
Beijing Friendship Hospital, Capital Medical University-Neurology
Beijing
Beijing Hospital-Neurology
Beijing
Beijing Huilongguan Hospital-Geriatrics
Beijing
Beijing Tiantan Hospital, Capital Medical University-Neurology Center
Beijing
Peking Union Medical College Hospital-Neurology
Beijing
Peking University Sixth Hospital-Geriatrics
Beijing
Xuanwu Hospital Capital Medical University-Neurology
Beijing
The First Bethune Hospital of Jilin University-Neurology
Changchun
The first Bethune Hospital of Jilin University, Neurology
Changchun
Xiangya Hospital Central South University-Neurology
Changsha
West China Hospital Sichuan University-Mental health center
Chengdu
The First Affiliated Hospital of Chongqing Medical University-Geriatrics
Chongqing
Fujian Medical University Union Hospital-Neurology
Fuzhou
Guangzhou First People's Hospital-Neurology
Guangzhou
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Neurology
Guangzhou
The Affiliated Brain Hospital of Guangzhou Medical University-Neurology
Guangzhou
The Second Affiliated Hospital of Guangzhou Medical University-Neurology
Guangzhou
The First Affiliated Hospital of Zhejiang University School of Medicine-Neurology
Hangzhou
The Second Affiliated Hospital of Nanchang University-Neurol
Nanchang
Nanjing Brain Hospital-Neurology
Nanjing
Nanjing Drum Tower Hospital-Neurology
Nanjing
Zhongda Hospital Southeast University-Nephrology
Nanjing
Dongfang Hospital Affiliated to Shanghai Tongji University-Neurology
Shanghai
Huashan Hospital Fudan University-Neurology
Shanghai
Shanghai 6th People's Hosp. Affili. to SHJT Univer-Neurology
Shanghai
Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Neurology
Shanghai
General Hospital of Tianjin Medical University-Neurology
Tianjin
Tianjin Huanhu Hospital-Neurology
Tianjin
Wuxi Mental Health Center
Wuxi
Wuxi Mental Health Center-Psychiatry
Wuxi
Qinghai Provincial People's Hospital-Geriatrics
Xining
Northern Jiangsu People's Hospital-Neurology
Yangzhou
Henan Provincial People's Hospital-Neurology
Zhengzhou
Croatia
KBC Zagreb, Klinika za neurologiju
Zagreb
Poliklinika Bonifarm
Zagreb
Poliklinika Solmed
Zagreb
Denmark
Aarhus Universitetshospital - Neurologisk Klinik
Aarhus N
Rigshospitalet - afsnit 8015 Hukommelsesklinikken
København Ø
Sjællands Universitetshospital_Roskilde
Roskilde
Finland
CRST Helsinki
Helsinki
Aivotutkimusyksikkö
Kuopio
CRST Turku
Turku
France
Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin
Bordeaux
Hospices Civils de Lyon-Hopital Pierre Wertheimer
Bron
Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
Dijon
Centre Hospitalier Universitaire de Lille-Hopital Roger Salengro
Lille
Centre Hospitalier Et Universitaire de Limoges-Hopital Dupuytren
Limoges
Assistance Publique Hopitaux de Marseille-Hopital de La Timone-1
Marseille
Centre Hospitalier Universitaire de Nice-Institut Claude Pompidou
Nice
Aphp-Hopital La Pitie Salpetriere-3
Paris
Aphp-Hopital Lariboisiere-1
Paris
Centre Hospitalier Universitaire Reims-Hopital Maison Blanche
Reims
Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-2
Saint-herblain
Les Hopitaux Universitaires de Strasbourg-Hopital de La Robertsau
Strasbourg
Centre Hospitalier Universitaire de Toulouse-Hopital La Grave
Toulouse
Hospices Civils de Lyon-Hopital Des Charpennes
Villeurbanne
Germany
Universitätsklinikum Köln - Klinik und Poliklinik für Psychiatrie und Psychotherapie
Cologne
Universitätsklinikum Münster - Neurologie
Münster
Greece
Aiginitio Hospital, 1st Neurology Clinic
Athens
Aiginitio Hospital, 1st Neurology Clinic
Athens
Henry Dunant Hospital Center,2nd Neurological Department
Athens
Hygeia General Hospital of Athens, Memory clinic
Athens
Naval Hospital of Athens
Athens
Naval Hospital of Athens
Athens
University General Hospital of Athens Attiko
Chaidari, Athens
Iatriko Athinon (Athens Medical Center),Memory Disorders Cli
Marousi
AHEPA General University Hospital
Thessaloniki
EUROMEDICA General Clinic of Thessaloniki,Neurology Dpt
Thessaloniki
Hungary
Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft.
Budapest
Semmelweis Egyetem ÁOK
Budapest
DE Gyógyszerfejlesztési Koordinációs Központ Pszichiátria
Debrecen
DE Kenézy Gyula Campus, Pszichiátriai és Pszichoterápiai Klinika
Debrecen
Bugát Pál Kórház
Gyöngyös
Petz Aladar Megyei Korhaz
Győr
Petz Aladar Megyei Oktato Korhaz
Győr
DR. MÁTHÉ ÉS TÁRSA Egészségügyi és Szolgáltató Betéti Társaság
Kalocsa
Somogy Megyei Kaposi Mór Oktató Kórház
Kaposvár
Psychotech Kft.
Pécs
Szent Borbála Kórház
Tatabánya
Belvárosi Egészségház Kft.
Zalaegerszeg
Ireland
Mercy Hospital Cork
Cork
Mercer's Institute for Successful Aging
Dublin
St Vincent's Neurology Dept
Dublin
St Vincent's University Hospital
Dublin
Tallaght University Hospital
Dublin
Israel
Rambam MC - The Stroke and Cognition Institute
Haifa
Rabin MC Beilinson - Cognitive Neurology Clinic
Petah Tikva
Sourasky MC - Cognitive Neurology Department
Tel Aviv
Sheba MC - Memory Clinic
Tel Hashomer, Ramat Gan
Italy
AOU Ospedali Riuniti S.O.D
Ancona
Azienda Ospedaliera Spedali Civili di Brescia
Brescia
Università degli studi G. D'Annunzio di Chieti - CAST - Neurologia
Chieti
AOU Careggi Firenze
Florence
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
Milan
IRCCS Ospedale San Raffaele Milano
Milan
ASST Monza e Brianza Ospedale San Gerardo
Monza
Ospedale Santa Maria della Misericordia
Perugia
Azienda Ospedaliero Universitaria Pisana
Pisa
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Neuroscienze, Organi di Senso e Torace
Roma
Fondazione Santa Lucia IRCCS
Roma
Pol. Uni. Campus Biomedico UOC Neurologia
Roma
Policlinico Tor Vergata
Roma
AOU Città della Salute e della Scienza di Torino
Torino
Japan
Iwaki Clinic_Psychosomatic medicine
Anan, Tokushima
Yachiyo Hospital_Neurology
Anjo-shi, Aichi
Abe Clinic
Arakawa-ku,tokyo
Memory Clinic Ochanomizu
Bunkyo-ku, Tokyo
Institute of Science Tokyo Hospital_ Neurology
Bunkyo-ku,tokyo
Tokyo Medical And Dental University Hospital
Bunkyo-ku,tokyo
Kashiwado Hospital
Chib-shi, Chiba
Kashiwado Hospital_Neurology
Chib-shi, Chiba
Enomoto Internal Medicine Clinic
Chofu-shi,tokyo
Shinozuka Hospital_Neurology
Fujioka-shi, Gunma
P-one Clinic
Hachioji-shi, Tokyo
National Hospital Organization Tenryu Hospital
Hamamatsu-shi, Shizuoka
Himeji Central Hospital Clinic
Himeji-shi, Hyogo
Hyogo Prefectural HarimaHimeji General Medical Center_Dept. of Aging Brain&Cognitive
Himeji-shi, Hyogo
Tsukazaki Hospital_Department of Neurology
Himeji-shi, Hyogo
Hatsuta Neurology Clinic
Hirakata-shi,osaka
Hikaru-kai Medical Corporation Hiroshima Neurology Clinic
Hiroshima-shi, Hiroshima
Hiroshima Neurology Clinic
Hiroshima-shi, Hiroshima
Imon Yukari Neurology Clinic
Hiroshima-shi, Hiroshima
Nagamitsu Clinic
Hofu-shi, Yamaguchi
Ina Central Hospital
Ina-shi, Nagano
Kawasaki Saiwai Clinic_Internal Medicine
Kanagawa
Kishiro Mental Clinic
Kawasaki-shi , Kanagawa
Koukan Clinic
Kawasaki-shi, Kanagawa
Teikyo University Hospital, Mizonokuchi_Kawasaki-shi, Kanagawa
Kawasaki-shi, Kanagawa
Kobe University Hospital
Kobe-shi, Hyogo
Kobe University Hospital_
Kobe-shi, Hyogo
National Center of Neurology and Psychiatry_Neurology
Kodaira-shi, Tokyo
Southern Tohoku Medical Clinic
Koriyama-shi, Fukushima
Katayama Medical Clinic
Kurashiki-shi, Okayama
Nozomi Memory Clinic
Mitaka-shi,tokyo
Kikukawa clinic
Nerima-ku, Tokyo
General Rehabilitation Center · Midori Hospital
Niigata-shi, Niigata
General Rehabilitation Center Midori Hospital_Neurology
Niigata-shi, Niigata
National Center for Geriatrics and Gerontology_Comprehensive care
Obu-shi, Aichi
OKAYAMA KYOKUTO HOSPITAL_Radiology
Okayama-shi, Okayama
Jichiidai Station Brain Clinic
Shimotsuke-shi, Tochigi
Jichiidai Station Brain Clinic
Shimotsuke-shi, Tochigi
Alzclinic Pet Lab
Shinjuku-ku, Tokyo
Keio University Hospital
Shinjuku-ku, Tokyo
Shizuoka City Shimizu Hospital_Neurology
Shizuoka-shi, Shizuoka
Kagawa Prefectural Central Hospital_Takamatsu-shi, Kagawa
Takamatsu-shi, Kagawa
Takatsuki General Hospital_Neurology
Takatsuki-shi, Osaka
Saino Clinic
Tokorozawa-shi,saitama
Itsuki Hospital_Neurology
Tokushima-shi, Tokushima
Alzclinic Tokyo
Tokyo
Juntendo Tokyo Koto Geriatric Medical Center
Tokyo
Juntendo Tokyo Koto Geriatric Medical Center_psychiatry
Tokyo
Kurumi CLINIC
Tokyo
Tokyo Center Clinic
Tokyo
Tokyo Medical Univ. Hospital
Tokyo
Memory Clinic Toride
Toride-shi, Ibaraki
MI Clinic
Toyonaka-shi, Osaka
Medical Corporation Midorikai Wako Hospital_Psychiatry
Wako-shi, Saitama
Yuaikai Yuai Clinic
Yokohama-shi, Kanagawa
Netherlands
Brain Research Center
's-hertogenbosch
Amphia Ziekenhuis
Breda
Spaarne Gasthuis
Haarlem
Radboudumc
Nijmegen
Poland
Centrum Medyczne Neuromed
Bydgoszcz
Centrum Zdrowia Psychicznego Biomed
Kielce
Centrum Neurologii Klinicznej
Krakow
Linden sp. z o.o. sp. k.
Krakow
Szpital Uniwersytecki w Krakowie od. Neurologii
Krakow
Indywidualna Praktyka Lekarska prof. Konrad Rejdak
Lublin
Nzoz Neuromed
Lublin
INSTYTUT ZDROWIA DR BOCZARSKA-JEDYNAKSp. z o.o. Sp. k.
Oświęcim
NZOZ NEURO - KARD Ilkowski i Partnerzy Sp. Part. Lekarzy
Poznan
Osrodek Alzheimerowski Sp. z o.o.
Ścinawa
Centrum Medyczne SENIOR
Sopot
Centrum Medyczne Neuro Protect
Warsaw
NZOZ Wrocławskie Centrum Alzheimerowskie
Wroclaw
Portugal
Unidade de Local de Saúde de Braga
Braga
Unidade Local de Saúde de Coimbra, E.P.E.
Coimbra
Unidade Local de Saude do Alto Ave, E.P.E.
Guimarães
Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital Egas Moniz
Lisbon
Hospital Beatriz Ângelo
Loures
Unidade Local de Saúde de Santo António, E.P.E
Porto
Unidade Local De Saude De Matosinhos E.P.E.
Senhora Da Hora, Matosinhos
Campus Neurológico Senior
Torres Vedras
Republic of Korea
Dong-A University Hospital
Busan
Chungnam National University Hospital
Daejeon
MyongJi Hospital
Goyang-si
Chonnam National University Hospital
Gwangju
Seoul National University Bundang Hospital
Gyeonggi-do
Gachon University Gil Medical Center
Incheon
Inha University Hospital
Incheon
Asan Medical Center
Seoul
Ewha Womans University Seoul Hospital
Seoul
Hanyang University Medical Center
Seoul
Hanyang university seoul hospital
Seoul
Konkuk University Medical Center
Seoul
Samsung Medical Center_Seoul
Seoul
Romania
Institutul Clinic Fundeni
Bucharest
Sana Monitoring SRL
Bucharest
Spitalul Clinic Cai Ferate Constanta
Constanța
Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
Constanța
Med Anima Iasi
Iași
CMI Dr. Buhaș Ramocea Elena Daniela - Cabinet Medical de Psihiarie
Oradea
Aria Clinic SRL
Sibiu
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş
Centrul Medical Neuro Therapy
Timișoara
CMI Neurologie Dr Popa Izabela
Timișoara
Russian Federation
SAI of Health Interregional Clinic Diagnostic Center
Kazan'
SAHI Kuzbass Hospital(former Regional clinical hospital)
Kemerovo
Federal Siberian Research Clinical Center under FMBA of Rus
Krasnoyarsk
FSAEI 1st Moscow Federal Med University na Sechenov
Moscow
FSBI Mental Health Research Center
Moscow
Pirogov Russian National Research Medical University MoH
Moscow
RMAPE
Moscow
Ezramed Clinic Llc
Omsk
Research Center for Treatment and Rehabilitation Phoenix
Rostov-on-don
N.-E. State Medical University n.a. Mechnikov
Saint Petersburg
Psychiatric hospital of st. Nicholas the wonderworker
Saint Petersburg
S.M. Kirov Military Medical Academy,Depart.&Clinic Nerv Dis
Saint Petersburg
SHI Saratov City Clinical Hospital #2 n.a. V.Razumovskij
Saratov
Center of Clinica Trials Nebbiolo
Tomsk
LLC Clinic Stolet
Tomsk
National medical holdiNational medical holding Medstandard
Ufa
Joint Stock Company Medical technologies
Yekaterinburg
SAHI SR Sverdlovsk Regional Clinical Psychiatric Hospital
Yekaterinburg
Serbia
Neurology clinic, University Clinical Center of Serbia
Belgrade
Special Hospital for Psychiatric Disorders Kovin
Kovin
University clinical center of Vojvodina, Neurology clinic
Novi Sad
Slovakia
I. neurologicka klinika LF UK a UNB
Bratislava
Psychiatricka klinika LF UK a UNB
Bratislava
Neurologicka klinika UPJS LF a UNLP
Košice
NEURES, neurologicka ambulancia
Krompachy
Crystal Comfort s.r.o.
Vranov Nad Topľou
Slovenia
UKC Ljubljana, Department of Neurology
Ljubljana
UKC Maribor - neurology
Maribor
Private Neurology Practice - Nova Gorica
Nova Gorica
South Africa
IATROS International
Bloemfontein
ACF Neurological service
Cape Town
Cape Trial Centre
Cape Town
Flexivest Fourteen Research Centre
Cape Town
Excellentis Clinical Trial Consultants
George
Dr Stanley Lipschitz Clinic Inc
Johannesburg
Denmar Psychiatric Hospital
Pretoria
Spain
Fundación ACE
Barcelona
Hospital de la Santa Creu i Sant Pau
Barcelona
Hospital 12 de Octubre
Madrid
Hospital Ramón y Cajal
Madrid
Hospital Universitario Quirónsalud Madrid
Pozuelo De Alarcón
Hospital Universitari General de Catalunya
Sant Cugat Del Vallès
Hospital Universitario Marqués de Valdecilla
Santander
Hospital Universitario Doctor Peset
Valencia
Sweden
Minnesmottagning specialiserad Malmö
Malmo
Karolinska Universitetssjukhuset, Huddinge
Stockholm
Geriatriskt centrum, Umeå
Umeå
Switzerland
Spitalzentrum Biel
Biel/bienne
Centre de la Mémoire
Geneva
Centre Leenaards de la mémoire CHUV
Lausanne
Klinik für Neurologie Kantonsspital St.Gallen
Sankt Gallen
Taiwan
Chang Gung Memorial Hospital - Kaohsiung Branch
Kaohsiung City
Chang Gung Memorial Hospital - Kaoshiung Branch
Kaohsiung City
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City
China Medical University Hospital
Taichung
National Cheng Kung University Hospital
Tainan
National Cheng Kung University Hospital
Tainan
National Taiwan University Hospital_main
Taipei
Taipei Veteran General Hospital
Taipei
Taipei Veteran General Hospital_Dept of Neurology
Taipei
Chang Gung Memorial Hospital Linkou
Taoyuan
Chang Gung Memorial Hospital, Linkou
Taoyuan District
Turkey
Hacettepe Üniversitesi Hastanesi- Nöroloji
Altindag/ankara
Hacettepe University Medical Faculty Hospital
Altindag/ankara
Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi- Nöroloji
Balcova / Izmir
Eskişehir Osmangazi Üniversitesi Hastanesi- Nöroloji
Eskişehir
Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma
Eskişehir
Istanbul Bezmi Alem Vakif University Tip Faculty Hospital
Istanbul
İstanbul Üniversitesi İstanbul Tıp Fakültesi Hastanesi- Nöroloji
Istanbul
Istanbul University Medical Faculty Neurology Department
Istanbul
Izmir Economics University Medical Point Hospital Neurology D
Izmir
İzmir Ekonomi Üniversitesi Medicalpoint Hastanesi-Nöroloji
Izmir
Ondokuz Mayis University Saglik Uygulama ve Arastirma Merkez
Samsun
Ondokuz Mayıs Üniversitesi Hastanesi- Nöroloji
Samsun
Ukraine
Chernivtsi Emergency Hospital - Center of Emergency Neurology
Chernivtsi
Medical Center 'Neiron'
Kharkiv
Medical Centre 'Neiron'
Kharkiv
Chebotarev Institute of Gerontology of NAMSU - Age Physiology and Pathology department
Kyiv
Volyn Regional Clinical Hospital - Neurology department
Lutsk
Main Unit of 'Odesa Regional Medical Centre for Mental Health' - Department 18
Odesa
Odesa Regional Medical Center for Mental Health
Odesa
Sumy Regional Clinical Hospital - Neurology department
Sumy
Medical Centre 'SALUTEM' - Medical and preventive care department
Vinnytsia
Zaporizhia Regional Clinical Hospital - Department of neurology No. 1
Zaporizhzhia
United Kingdom
Royal Cornhill Hospital
Aberdeen
RICE - The Research Institute for the Care of Older People
Bath
Fritchie Centre
Cheltenham
Dementia Research Unit
Crowborough
Dementia Research Unit,
Crowborough
Ninewells Hospital
Dundee
Western General Hospital
Edinburgh
Imperial College London - Imperial College Memory Research Centre
London
St George's Hospital
London
St Pancras Clinical Research
London
Greater Manchester Mental Health NHS Foundation Trust
Manchester
NeuroClin
Motherwell
Newcastle University
Newcastle Upon Tyne
Warneford Hospital
Oxford
Moorgreen Hospital
Southampton
Kings Hill Research Centre
Swindon
Time Frame
Start Date: 2021-05-18
Completion Date: 2026-10-06
Participants
Target number of participants: 1840
Treatments
Experimental: Oral semaglutide
Participants are given oral semaglutide once daily
Placebo_comparator: Placebo (semaglutide)
Participants are given oral placebo once daily
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S