MotIoN aDaptive Deep Brain Stimulation for MSA

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and published evidence shows, that stimulation has effects on the autonomic nervous system. In patients undergoing therapeutic DBS for a particular subtype of Parkinsonism (Multiple System Atrophy), the effects on autonomic parameters such as blood pressure and bladder symptoms has been shown to be improved by the investigators (unpublished data). In this current study, the investigators plan to use a novel technique of adaptive DBS in order to provide stimulation dependent on patient physiological or positional factors. This is with the aim of making stimulation more responsive and patient-specific.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Healthy Volunteers: f
View:

• Diagnosis of MSA with disabling autonomic symptoms

• \>6/12 in the autonomic subsection (Q9-12) of the UMSAR scale

• Patient willing and able to give informed consent to involvement in the study.

• Male or female aged 55 years or over

• Able to walk (to perform gait analysis)

• Have an anticipated prognosis \> 2 years

Locations
Other Locations
United Kingdom
John Radcliffe Hospital
RECRUITING
Oxford
Time Frame
Start Date: 2021-12-03
Estimated Completion Date: 2025-08-01
Participants
Target number of participants: 5
Treatments
Experimental: Deep brain stimulation
All patients will undergo adaptive deep brain stimulation with results compared before and after stimulation
Sponsors
Leads: University of Oxford
Collaborators: Oxford University Hospitals NHS Trust

This content was sourced from clinicaltrials.gov

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