Adult Soft Tissue Sarcoma Overview
Learn About Adult Soft Tissue Sarcoma
Soft tissue sarcoma (STS) is cancer that forms in the soft tissue of the body. Soft tissue connects, supports, or surrounds other body parts. In adults, STS is rare.
There are many different types of soft tissue cancers. The type of sarcoma depends on the tissue it forms in:
- Muscles
- Tendons
- Fat
- Blood vessels
- Lymph vessels
- Nerves
- Tissues in and around joints
The cancer can form almost anywhere, but is most common in the:
- Head
- Neck
- Arms
- Legs
- Trunk
- Abdomen
STS; Leiomyosarcoma; Hemangiosarcoma; Kaposi's sarcoma; Lymphangiosarcoma; Synovial sarcoma; Neurofibrosarcoma; Liposarcoma; Fibrosarcoma; Malignant fibrous histiocytoma; Dermatofibrosarcoma; Angiosarcoma
It is not known what causes most sarcomas. But there are certain risk factors:
- Some inherited diseases, such as Li-Fraumeni syndrome
- Radiation therapy for other cancers
- Exposure to certain chemicals, such as vinyl chloride or certain herbicides
- Having swelling in the arms or legs for a long time (lymphedema)
In early stages, there are often no symptoms. As the cancer grows, it may cause a lump or swelling that keeps growing over time. Most lumps are not due to cancer.
Other symptoms include:
- Pain, if it presses on a nerve, organ, blood vessel, bone, or muscle
- Blockage or bleeding in the stomach or intestines
- Breathing problems
Surgery is the most common treatment for STS.
- In early stages, the tumor and some healthy tissue around it is removed.
- Sometimes, just a small amount of tissue needs to be removed. Other times, a wider area of tissue must be removed.
- With advanced cancers that form in an arm or leg, surgery may be followed by radiation therapy or chemotherapy. Rarely, the limb may need to be amputated.
You also may have radiation therapy or chemotherapy:
- Used before surgery to help shrink the tumor to make it easier to remove the cancer
- Used after surgery to kill any remaining cancer cells
Chemotherapy may be used to help kill cancer that has metastasized. This means it has spread to different areas of the body.
Healthtexas Provider Network
Aravind Sanjeevaiah is an Oncologist and a Hematologist Oncology provider in Waxahachie, Texas. Dr. Sanjeevaiah and is rated as an Advanced provider by MediFind in the treatment of Adult Soft Tissue Sarcoma. His top areas of expertise are Colorectal Cancer, Neuroendocrine Tumor, Stomach Cancer, and Gastrointestinal Stromal Tumor. Dr. Sanjeevaiah is currently accepting new patients.
Edward Middleman is an Oncologist and a Hematologist Oncology provider in Duncanville, Texas. Dr. Middleman and is rated as an Experienced provider by MediFind in the treatment of Adult Soft Tissue Sarcoma. His top areas of expertise are Angiosarcoma, Inflammatory Breast Cancer, Thrombocytopenia, and Familial Colorectal Cancer. Dr. Middleman is currently accepting new patients.
Texas Oncology PA
Darshan Gandhi is a Hematologist Oncology specialist and an Oncologist in Dallas, Texas. Dr. Gandhi and is rated as an Experienced provider by MediFind in the treatment of Adult Soft Tissue Sarcoma. His top areas of expertise are Paget Disease of the Breast, Familial Colorectal Cancer, Multiple Myeloma, and Pleuropulmonary Blastoma. Dr. Gandhi is currently accepting new patients.
Cancer affects how you feel about yourself and your life. You can ease the stress of illness by joining a cancer support group. Sharing with others who have had the same experiences and problems can help you feel less alone.
Ask your provider to help you find a support group for people who have been diagnosed with STS.
The outlook for people whose cancer is treated early is very good. Most people who survive 5 years can expect to be cancer-free at 10 years.
Complications include side effects from surgery, chemotherapy, or radiation.
See your provider about any lump that grows in size or is painful.
The cause of most STSs isn't known and there is no way to prevent it. Knowing your risk factors and telling your provider when you first notice symptoms can increase your chance of surviving this type of cancer.
Summary: This phase I trial tests the safety, side effects, and best dose of combination therapy with liposomal doxorubicin and peposertib in treating patients with sarcoma that has spread from where it first started, to other places in the body (metastatic), or cannot be removed by surgery (unresectable) and for which no known cure is available (advanced). Doxorubicin is in a class of medications called a...
Summary: AGX101 is an antibody-drug conjugate (ADC) therapy for tumor-forming cancers. The purpose of this study is to learn about AGX101 effects and safety at various dose levels in an all-comers advanced solid cancer patient population. AGX101will be administered intravenously. Dosing of AGX101 will be repeated once every 3, 6 or 9 weeks. Participants may continue study treatment until disease progressio...
Published Date: August 21, 2024
Published By: Warren Brenner, MD, Oncologist, Lynn Cancer Institute, Boca Raton, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Contreras CM, Heslin MJ. Soft tissue sarcoma. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. St Louis, MO: Elsevier; 2022:chap 32.
National Cancer Institute website. Soft tissue sarcoma treatment (PDQ) - health professional version. www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq#section/all. Updated April 10, 2024. Accessed August 29, 2024.
Van Tine BA. Sarcomas of soft tissue. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 90.