• Fulfilling all the following criteria before initiation of comprehensive treatment:

‣ 1 18 years of age or older, male or female.

‣ 2 Negative result of urine or blood pregnancy test for females with childbearing potential (not post-menopausal or surgically sterile).

‣ 3 Prior history of coronary revascularization (percutaneous coronary intervention \[PCI\] or coronary artery bypass graft \[CABG\]).

‣ 4 Receiving standard treatment for secondary prevention of atherosclerotic coronary artery disease (AS-CAD) after the last coronary revascularization.

‣ 5 Hospitalization due to rapidly-progressive myocardial ischemia:

⁃ Typical symptoms of angina (Canadian Cardiovascular Society \[CCS\] III-IV) and non-invasive evidence of myocardial ischemia; and

⁃ Occurred within 6 months or occurred on immunosuppressive therapy within 12 months of the last coronary revascularization.

‣ 6 Angiographic evidence of new coronary lesions (de novo stenoses or restenoses):

⁃ Occurred after the last coronary revascularization; and

⁃ Related to myocardial ischemia (location, extent, severity, et al).

‣ 7 Evidence of inflammation:

⁃ At least one of the markers indicating active inflammation has ever been elevated (erythrocyte sedimentation rate \[ESR\], high-sensitivity C-reactive protein \[hs-CRP\], interleukin \[IL\]-6, tumor necrosis factor \[TNF\]-α, ferritin, et al); or

⁃ Established diagnosis of systemic autoimmune disease or systemic vasculitis; or

⁃ Receiving immunosuppressive therapy.

• Receiving comprehensive treatment, including ischemia-driven PCI which was performed no earlier than 40 days of the initiation of immunosuppressive therapy.