Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia: a Prospective Cohort Study (The PROPHECY Study)
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Newly prescribed thiazide or thiazide-like diuretic
• ≥ 18 years of age
• Informed Consent as documented by signature
Locations
Other Locations
Spain
Hospital Universitario de Móstoles
RECRUITING
Móstoles
Switzerland
University Hospital Basel, Endocrinology, Diabetes and Metabolism
RECRUITING
Basel
Kantonsspital Baselland
RECRUITING
Liestal
Contact Information
Primary
Julia Beck, Dr. med.
julia.beck@usb.ch
+41 61 328 54 37
Backup
Joyce Santos de Jesus
joyce.santosdejesus@usb.ch
Time Frame
Start Date: 2022-09-26
Estimated Completion Date: 2026-07
Participants
Target number of participants: 232
Treatments
Patients with newly prescribed thiazide or thiazide-like diuretic
As the study population of this observational study shall be as representative as possible all patients with a new thiazide or thiazide-like diuretic regardless of the indication, co-morbidities and co-medication can be included.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Basel, Switzerland