Phase II Trial of Lung Chemoemobolization

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure, Device, Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This phase II trial evaluates how well transarterial chemoembolization (TACE) works for treating patients with non-small cell lung cancer or lung metastases. TACE is a minimally invasive procedure that involves injecting chemotherapy directly into an artery that supplies blood to tumors, and then blocking off the blood supply to the tumors. Mitomycin (chemotherapy), Lipiodol (drug carrier), and Embospheres (small plastic beads that block off the artery) are injected into the tumor-feeding artery. This traps the chemotherapy inside the tumor and also cuts off the tumor\'s blood supply. As a result, the tumor is exposed to a high dose of chemotherapy, and is also deprived of nutrients and oxygen. TACE can be effective at controlling or stopping the growth of lung tumors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Lung cancer or lung metastases, with lung, endobronchial, pleural, or mediastinal tumors that are progressing on systemic therapy (or the patient cannot tolerate systemic therapy), and that are not amenable to resection, thermal ablation, or ablative radiation therapy

• Lung-dominant disease (majority of active tumor volume is in the chest)

• At least 18 years old

Locations
United States
California
City of Hope Medical Center
RECRUITING
Duarte
New York
Memorial Sloan Kettering Cancer Center
RECRUITING
New York
Contact Information
Primary
Franz Edward Boas, MD
fboas@coh.org
626-218-8708
Time Frame
Start Date: 2023-05-12
Estimated Completion Date: 2026-10-28
Participants
Target number of participants: 30
Treatments
Experimental: Lung chemoembolization
Patients receive lipiodol intra-arterially (IA), mitomycin IA, and embospheres IA and undergo TACE on study. Patients also undergo angiography and computed tomography (CT) at baseline and follow up.
Sponsors
Leads: City of Hope Medical Center
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov

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