A Multicenter, Randomized Controlled Trial, Prospectively Evaluating the Clinical Utility of the Nodify XL2 Proteomic Classifier in Incidentally Discovered Low to Moderate Risk Lung Nodules

Status: Active_not_recruiting
Location: See all (25) locations...
Study Type: Observational
SUMMARY

This study evaluates the how addition of the Nodify XL2 test result impacts the clinical management of newly identified solid lung nodules assessed as low to moderate risk of cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
View:

• Subject has provided informed consent to participate in the study and agrees to comply with all protocol requirements

• Subject is \> 40 years of age at the time of the discovery of the lung nodule of concern

• Subject's lung nodule of concern meets the following:

‣ Was incidentally identified or detected during lung cancer screening

⁃ Is a solid nodule

⁃ Has maximal dimension of \> 8mm and \< 30mm

• The first CT scan identifying the lung nodule of concern was performed within 60 days of subject enrollment

• The pre-test risk of cancer as determined by the Mayo risk prediction algorithm is 65% or less

Locations
United States
Colorado
University of Colorado
Aurora
Connecticut
Beth Israel Deaconess
Boston
Massachusetts General Hospital
Boston
Washington, D.c.
MedStar
Washington D.c.
Indiana
Indiana University
Indianapolis
Maryland
The Johns Hopkins University
Baltimore
Michigan
University of Michigan
Ann Arbor
Minnesota
Mayo Clinic
Rochester
Missouri
The Washington University
St Louis
North Carolina
The University of North Carolina
Chapel Hill
Duke University
Durham
Southeastern Research Center
Winston-salem
New York
Mount Sinai Health System
New York
Northwell Health
New York
Ohio
Cleveland Clinic
Cleveland
The Ohio State University
Coulmbus
Oregon
The Oregon Clinic
Portland
South Carolina
Medical University of South Carolina
Charleston
Ralph H Johnson VA Medical Center
Charleston
Prisma Health
Greenville
Texas
University of Texas Southwestern
Dallas
University of Texas Medical Branch
Galveston
Virginia
Virginia Commonwealth University
Richmond
Other Locations
Canada
University of Calgary
Calgary
McGill University Health Centre
Montreal
Time Frame
Start Date: 2020-12-18
Completion Date: 2026-12
Participants
Target number of participants: 2000
Treatments
Open Label
Nodify XL2 results will be reported to the investigator and available to the subject.
Blinded
Nodify XL2 results will not be available to the investigative site or subject.
Related Therapeutic Areas
Sponsors
Leads: Biodesix, Inc.

This content was sourced from clinicaltrials.gov