The circulatory and lymphatic systems play vital roles at the capillary level and throughout our bodies. Venous disease can lead to water-rich edema which this fluid is removed by an intact lymphatic system. However, if the lymphatic system is constantly tasked with removing edema, it can becomes damaged over time. Proper management of both systems is essential, as these progressive diseases can result in skin changes and wounds. Timely recognition and appropriate treatment is key in promoting early disease management, prevention of complications, and a healing trajectory.