Cost-utility Analysis of Ambulatory Dose Escalation of Bispecific Antibodies in Multiple Myeloma.

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Multiple myeloma is the second most common haematological cancer. Recent innovations have made it possible for relapsed/refractory patients to benefit from the innovative immunotherapy of bispecific antibodies. These antibodies stimulate the immune system to attack tumour cells. The treatment involves an escalating dose of three subcutaneous injections every 2 to 4 days for a total of about 10 days, followed by a weekly treatment phase. The University Hospital of Toulouse was the first centre in France to offer outpatient dose escalation for this innovative treatment. This form of treatment depends on clinical and logistical feasibility. Where appropriate, patients are treated in a conventional unit. An analysis carried out at Toulouse University Hospital suggests a response to treatment, with no increased risk of complications in the outpatient setting. Patients' quality of life may also be unaffected. In addition, given the increasing demand for care in a context of finite resources, the economic evaluation of healthcare initiatives is becoming essential if we are to maintain a high-quality healthcare system that is accessible to all.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Relapsed and/or refractory multiple myeloma

• Treated with teclistamab, elranatamab ou talquetamab

• More than 18 years old

• Having received the information from the study and not having objected to participate

• Day hospital care in case of clinical feasibility (good general condition, no rapid progression or major tumor burden, no current infection) and logistics (accommodated less than 30 minutes from the IUCT Oncopole for 48 hours after each dose escalation) or in conventional hospitalization at the IUCT Oncopole

Locations
Other Locations
France
CHU de Toulouse
RECRUITING
Toulouse
Contact Information
Primary
Aurore PERROT, Md, PhD
perrot.aurore@iuct-oncopole.fr
0531155050
Time Frame
Start Date: 2025-01-20
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 40
Treatments
Outpatient step-up dose procedure
Patients treated on an outpatient procedure if it's clinically feasible (good condition general, no rapid progression or major tumor burden, no current infection) and logistics (lived within 30 minutes from the IUCT Oncopole for 48 hours after each step-up dose)
Conventional procedure
Patients who do not meet the conditions for outpatient care and justify hospitalization in a conventional unit for dose escalation
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Toulouse

This content was sourced from clinicaltrials.gov