Restoration of Immunity to Vaccine Preventable Diseases After CART-T Cell Therapy

Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Observational
SUMMARY

The goal of this observational study is to learn about vaccine immunity in patients with B-cell malignancies treated by chimeric antigen receptor T-cell therapies (CAR-T). The main questions it aims to answer are: * Do CAR-T cell therapy recipients lose vaccine protection against common vaccine-preventable pathogens * Are current re-vaccination recommendations sufficient in restoring vaccine-protection * Is this restored vaccine-protection after CAR-T cell therapy lost faster than usual * Do clinical or immunological factors predict vaccine response after CAR-T cell therapy

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient ≥ 18 years old

• Suffering from a B-cell malignancy (B-cell acute lymphoblastic leukemia (ALL), B-cell non-hodgkin lymphoma (NHL), Follicular lymphoma (FL), Mantle Cell Lymphoma (MCL), Multiple myeloma (MM))

• Planned for a CAR-T cell therapy

• Provided written informed consent

Locations
Other Locations
Switzerland
University Hospital Bern
RECRUITING
Bern
Contact Information
Primary
Lukas N Baumann, MD
lukas.baumann2@insel.ch
+41 31 664 3069
Backup
Cédric Hirzel, PD, MD
cedric.hirzel@insel.ch
+41 31 66 4 01 17
Time Frame
Start Date: 2023-11-14
Estimated Completion Date: 2026-12
Participants
Target number of participants: 80
Treatments
CAR T-cell recipients
Patients with B-cell malignancies receiving anti-CD19 or anti-BCMA CAR T-cell therapies
Sponsors
Leads: Insel Gruppe AG, University Hospital Bern

This content was sourced from clinicaltrials.gov

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