Identification and Validation of a Biomarker for Tinnitus: an Objective Data-driven Personalized Approach to Diagnosis of Chronic Tinnitus - The Tinnitus Detection (TIDE) Project

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Research in clinical neuroscience is founded on the conviction that a better understanding of tinnitus related changes of brain function will improve our ability to diagnose and treat tinnitus. Although considerable advances have been made in understanding the mechanisms of tinnitus, the clinical management of tinnitus remains largely based on a 'trial and error' approach. The identification and validation of a biomarker for tinnitus is thought to be the crucial step in the development of a personalized approach to the diagnosis and treatment of tinnitus. The overarching goal of this study is to incorporate advanced technologies to provide an objective, data-driven, personalized approach to the diagnosis of chronic tinnitus. This should lead to a clinically applicable tool that can be widely and easily used.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:

⁃ (1) for tinnitus cases: a diagnosis of chronic and constant tinnitus (for at least 6 months based on history)

• (2) for controls: never experienced tinnitus

• (3) age 18 -70;

• (4) ability to understand and consent to the research;

• (5) ability to participate (hearing ability);

• (6) MoCa Test ≥ 26;

• (7) hyperacusis questionnaire score \< 27;

• (8) Hospital Anxiety and Depression Scale (HADS) \<14;

Locations
United States
Illinois
University of Illinois
RECRUITING
Champaign
Texas
University of Texas
RECRUITING
Austin
Other Locations
Belgium
Brai3n - Research center for Advanced, International, Innovative and Interdisciplinary Neuromodulation
RECRUITING
Ghent
Germany
Center of Neuromodulation - Psychiatry und Psychotherapie der Universität Regensburg am Bezirksklinikum
RECRUITING
Regensburg
University of Tuebingen
RECRUITING
Tübingen
Ireland
Trinity College Dublin
RECRUITING
Dublin
Switzerland
OST - Eastern Switzerland University of Applied Sciences
RECRUITING
Sankt Gallen
Contact Information
Primary
Berthold Langguth, Prof.
berthold.langguth@medbo.de
+49 941 941
Backup
Susanne Staudinger, M.A.
susanne.staudinger@medbo.de
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 560
Treatments
Tinnitus cases/patients
Subjects that have a diagnosis of chronic and constant tinnitus (for at least 6 months based on history)
Control group
Subjects that never experienced tinnitus (excluding short-term tinnitus, i.e. not tinnitus that persists over a longer period of time)
Related Therapeutic Areas
Sponsors
Collaborators: University of Dublin, Trinity College, University of Illinois at Urbana-Champaign, University of Texas at Austin, Brain - Brain Research Center for Advanced, Innovative, Interdisciplinary and International Neuromodulation, Universität Tübingen, University Hospital, Zürich, Eastern Switzerland University of Applied Sciences
Leads: University of Regensburg

This content was sourced from clinicaltrials.gov