Diagnostic Tools for the Direct Detection of Orientia Tsutsugamushi
Evaluate the performance of insulated isothermal polymerase chain reaction (iiPCR) in the diagnosis of scrub typhus in Chiang Rai Province
• Acute (duration ≤14 days) fever (37.5°C or higher or a history of fever in the previous 24h) AND
• Eschar OR
• ≥ 2 of the following:
• Living in rural parts of Chiangrai Province or other ST risk areas
• History of outdoor risk activities in the 2 weeks before symptom onset
• Presenting during the rainy season or early cold season
• Two or more of: headache; myalgia, cough, abdominal symptoms (abdominal pain/ nausea-vomiting); myalgia; lymphadenopathy AND
• ≥ 7 years old AND
• Weight\>15Kg AND
• The patient and/or where relevant their parent/guardian/caretaker/legally acceptable representative willing and able to give informed consent /assent for participation in the study AND Positivity to any of the screening tests (Immunochromatographic RDT or iiPCR)