Diagnostic Tools for the Direct Detection of Orientia Tsutsugamushi

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Evaluate the performance of insulated isothermal polymerase chain reaction (iiPCR) in the diagnosis of scrub typhus in Chiang Rai Province

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Healthy Volunteers: f
View:

• Acute (duration ≤14 days) fever (37.5°C or higher or a history of fever in the previous 24h) AND

• Eschar OR

• ≥ 2 of the following:

• Living in rural parts of Chiangrai Province or other ST risk areas

• History of outdoor risk activities in the 2 weeks before symptom onset

• Presenting during the rainy season or early cold season

• Two or more of: headache; myalgia, cough, abdominal symptoms (abdominal pain/ nausea-vomiting); myalgia; lymphadenopathy AND

• ≥ 7 years old AND

• Weight\>15Kg AND

• The patient and/or where relevant their parent/guardian/caretaker/legally acceptable representative willing and able to give informed consent /assent for participation in the study AND Positivity to any of the screening tests (Immunochromatographic RDT or iiPCR)

Locations
Other Locations
Thailand
Mae Chan District Hospital
RECRUITING
Mae Chan
Contact Information
Primary
Carlo Perrone, MD
carlo@tropmedres.ac
+66 5202 9842
Backup
Nidanuch Tasak
nidanuch@tropmedres.ac
+66 5202 9842
Time Frame
Start Date: 2024-07-17
Estimated Completion Date: 2025-04-30
Participants
Target number of participants: 100
Treatments
Suscpected scrub typhus cases
Participants with symptoms and epidemiologic risks for of scrub typhus and testing positive by:~1. StandardQ rapid diagnostic test OR~2. InBios Scrub Typhus Detect IgM~3. Insulated isothermal PCR
Related Therapeutic Areas
Sponsors
Leads: University of Oxford

This content was sourced from clinicaltrials.gov