A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
Status: Completed
Location: See all (183) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 30
Healthy Volunteers: f
View:
• Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
• In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood
• Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse
• No concurrent systemic antileukemic treatment administered for current relapse
‣ Intrathecal chemotherapy allowed
⁃ On-therapy relapse allowed
Locations
United States
Alabama
Children's Hospital of Alabama
Birmingham
University of Alabama at Birmingham Cancer Center
Birmingham
Arkansas
Arkansas Children's Hospital
Little Rock
University of Arkansas for Medical Sciences
Little Rock
Arizona
Phoenix Childrens Hospital
Phoenix
Banner University Medical Center - Tucson
Tucson
California
Kaiser Permanente Downey Medical Center
Downey
City of Hope Comprehensive Cancer Center
Duarte
Loma Linda University Medical Center
Loma Linda
Miller Children's and Women's Hospital Long Beach
Long Beach
Children's Hospital Los Angeles
Los Angeles
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles
Valley Children's Hospital
Madera
Children's Hospital and Research Center at Oakland
Oakland
Kaiser Permanente-Oakland
Oakland
Children's Hospital of Orange County
Orange
Lucile Packard Children's Hospital Stanford University
Palo Alto
Sutter Medical Center Sacramento
Sacramento
University of California Davis Comprehensive Cancer Center
Sacramento
Naval Medical Center -San Diego
San Diego
Rady Children's Hospital - San Diego
San Diego
UCSF Medical Center-Mission Bay
San Francisco
UCSF Medical Center-Parnassus
San Francisco
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance
Colorado
Children's Hospital Colorado
Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver
Connecticut
Connecticut Children's Medical Center
Hartford
Washington, D.c.
Children's National Medical Center
Washington
MedStar Georgetown University Hospital
Washington
Delaware
Alfred I duPont Hospital for Children
Wilmington
Florida
Broward Health Medical Center
Fort Lauderdale
Golisano Children's Hospital of Southwest Florida
Fort Myers
Lee Memorial Health System
Fort Myers
University of Florida Health Science Center - Gainesville
Gainesville
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood
Nemours Children's Clinic-Jacksonville
Jacksonville
Miami Cancer Institute
Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami
AdventHealth Orlando
Orlando
Arnold Palmer Hospital for Children
Orlando
Nemours Children's Clinic - Orlando
Orlando
Nemours Children's Hospital
Orlando
UF Cancer Center at Orlando Health
Orlando
Nemours Children's Clinic - Pensacola
Pensacola
Johns Hopkins All Children's Hospital
Saint Petersburg
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa
Tampa General Hospital
Tampa
Saint Mary's Hospital
West Palm Beach
Georgia
Children's Healthcare of Atlanta - Egleston
Atlanta
Hawaii
Kapiolani Medical Center for Women and Children
Honolulu
University of Hawaii Cancer Center
Honolulu
Iowa
Blank Children's Hospital
Des Moines
University of Iowa/Holden Comprehensive Cancer Center
Iowa City
Idaho
Saint Luke's Mountain States Tumor Institute
Boise
Illinois
Lurie Children's Hospital-Chicago
Chicago
University of Chicago Comprehensive Cancer Center
Chicago
University of Illinois
Chicago
Advocate Children's Hospital-Oak Lawn
Oak Lawn
Advocate Children's Hospital-Park Ridge
Park Ridge
Advocate Lutheran General Hospital
Park Ridge
Saint Jude Midwest Affiliate
Peoria
Southern Illinois University School of Medicine
Springfield
Indiana
Riley Hospital for Children
Indianapolis
Saint Vincent Hospital and Health Care Center
Indianapolis
Kansas
University of Kansas Cancer Center
Kansas City
Kentucky
University of Kentucky/Markey Cancer Center
Lexington
Norton Children's Hospital
Louisville
Louisiana
Children's Hospital New Orleans
New Orleans
Ochsner Medical Center Jefferson
New Orleans
Tulane University Health Sciences Center
New Orleans
Massachusetts
UMass Memorial Medical Center - University Campus
Worcester
Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore
Sinai Hospital of Baltimore
Baltimore
University of Maryland/Greenebaum Cancer Center
Baltimore
Walter Reed National Military Medical Center
Bethesda
Michigan
Ascension Saint John Hospital
Detroit
Wayne State University/Karmanos Cancer Institute
Detroit
Michigan State University Clinical Center
East Lansing
Hurley Medical Center
Flint
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids
Bronson Methodist Hospital
Kalamazoo
Kalamazoo Center for Medical Studies
Kalamazoo
Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis
University of Minnesota/Masonic Cancer Center
Minneapolis
Mayo Clinic
Rochester
Missouri
Columbia Regional
Columbia
Children's Mercy Hospitals and Clinics
Kansas City
Mercy Hospital Saint Louis
Saint Louis
Washington University School of Medicine
Saint Louis
Mississippi
University of Mississippi Medical Center
Jackson
North Carolina
Mission Hospital
Asheville
UNC Lineberger Comprehensive Cancer Center
Chapel Hill
Carolinas Medical Center/Levine Cancer Institute
Charlotte
Novant Health Presbyterian Medical Center
Charlotte
Duke University Medical Center
Durham
East Carolina University
Greenville
Wake Forest University Health Sciences
Winston-salem
North Dakota
Sanford Broadway Medical Center
Fargo
Nebraska
Children's Hospital and Medical Center of Omaha
Omaha
University of Nebraska Medical Center
Omaha
New Hampshire
Dartmouth Hitchcock Medical Center
Lebanon
New Jersey
Hackensack University Medical Center
Hackensack
Morristown Medical Center
Morristown
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick
Saint Peter's University Hospital
New Brunswick
Newark Beth Israel Medical Center
Newark
Saint Joseph's Regional Medical Center
Paterson
Overlook Hospital
Summit
New Mexico
University of New Mexico Cancer Center
Albuquerque
Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas
Nevada Cancer Research Foundation CCOP
Las Vegas
Summerlin Hospital Medical Center
Las Vegas
Sunrise Hospital and Medical Center
Las Vegas
University Medical Center of Southern Nevada
Las Vegas
New York
Albany Medical Center
Albany
Montefiore Medical Center - Moses Campus
Bronx
Roswell Park Cancer Institute
Buffalo
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York
University of Rochester
Rochester
Stony Brook University Medical Center
Stony Brook
State University of New York Upstate Medical University
Syracuse
New York Medical College
Valhalla
Ohio
Children's Hospital Medical Center of Akron
Akron
Cleveland Clinic Foundation
Cleveland
Rainbow Babies and Childrens Hospital
Cleveland
Nationwide Children's Hospital
Columbus
Dayton Children's Hospital
Dayton
Oklahoma
University of Oklahoma Health Sciences Center
Oklahoma City
Oregon
Legacy Emanuel Children's Hospital
Portland
Legacy Emanuel Hospital and Health Center
Portland
Oregon Health and Science University
Portland
Pennsylvania
Lehigh Valley Hospital - Muhlenberg
Bethlehem
Penn State Children's Hospital
Hershey
Children's Hospital of Philadelphia
Philadelphia
Childrens Oncology Group
Philadelphia
Saint Christopher's Hospital for Children
Philadelphia
Children's Hospital of Pittsburgh of UPMC
Pittsburgh
Rhode Island
Rhode Island Hospital
Providence
South Carolina
Prisma Health Richland Hospital
Columbia
BI-LO Charities Children's Cancer Center
Greenville
Greenville Cancer Treatment Center
Greenville
South Dakota
Sanford USD Medical Center - Sioux Falls
Sioux Falls
Tennessee
T C Thompson Children's Hospital
Chattanooga
East Tennessee Childrens Hospital
Knoxville
Vanderbilt University/Ingram Cancer Center
Nashville
Texas
Texas Tech University Health Sciences Center-Amarillo
Amarillo
Driscoll Children's Hospital
Corpus Christi
Medical City Dallas Hospital
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Dallas
Brooke Army Medical Center
Fort Sam Houston
Cook Children's Medical Center
Fort Worth
Covenant Children's Hospital
Lubbock
Children's Hospital of San Antonio
San Antonio
Methodist Children's Hospital of South Texas
San Antonio
University of Texas Health Science Center at San Antonio
San Antonio
Utah
Primary Children's Hospital
Salt Lake City
Virginia
Children's Hospital of The King's Daughters
Norfolk
Carilion Clinic Children's Hospital
Roanoke
Vermont
University of Vermont and State Agricultural College
Burlington
Washington
Seattle Children's Hospital
Seattle
Providence Sacred Heart Medical Center and Children's Hospital
Spokane
Madigan Army Medical Center
Tacoma
Mary Bridge Children's Hospital and Health Center
Tacoma
Wisconsin
Saint Vincent Hospital Cancer Center Green Bay
Green Bay
Marshfield Medical Center-Marshfield
Marshfield
Children's Hospital of Wisconsin
Milwaukee
West Virginia
West Virginia University Charleston Division
Charleston
Other Locations
Australia
Princess Margaret Hospital for Children
Perth
Canada
IWK Health Centre
Halifax
Kingston Health Sciences Centre
Kingston
Children's Hospital
London
Centre Hospitalier Universitaire Sainte-Justine
Montreal
The Montreal Children's Hospital of the MUHC
Montreal
Children's Hospital of Eastern Ontario
Ottawa
Allan Blair Cancer Centre
Regina
Saskatoon Cancer Centre
Saskatoon
Hospital for Sick Children
Toronto
British Columbia Children's Hospital
Vancouver
CancerCare Manitoba
Winnipeg
Puerto Rico
San Jorge Children's Hospital
San Juan
University Pediatric Hospital
San Juan
Switzerland
Swiss Pediatric Oncology Group - Bern
Bern
Time Frame
Start Date: 2006-09-25
Completion Date: 2019-12-31
Participants
Target number of participants: 811
Treatments
Ancillary-Correlative (Collecting and banking ALL specimens)
Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.
Authors
Violet Shen, Madhvi Rajpurkar, Mandy M. Atkinson, Joseph M. Wiley, Glen Lew, Neyssa M. Marina, Barbara J. Bambach, Marcio H. Malogolowkin, Jessica C. Hochberg, Anna B. Pawlowska, Douglas S. Hawkins, Luis A. Clavell, Rene Y. McNall-Knapp, Eric J. Lowe, Karol H. Kerr, Ronnie W. Neuberg, Anne B. Warwick, Jessica Boklan, Arthur K. Ritchey, Stanton C. Goldman, Michael S. Isakoff, Kayelyn J. Wagner, Thomas W. Loew, Phillip E. Barnette, Howard M. Katzenstein, Timothy C. Griffin, Vonda L. Crouse, Vincent F. Giusti, Doured Daghistani, Christopher P. Keuker, Iftikhar Hanif, Aron Flagg, Mark A. Ranalli, Latha Prasannan, Leo Mascarenhas, Ray C. Pais, Kenneth M. Heym, Gerardo Quezada, Renuka Gera, Vikramjit S. Kanwar, Paulette C. Bryant, Narayana Gowda, Manoo G. Bhakta, Linda C. Stork, Stephen Hunger, Craig Lotterman, Burton E. Appel, Nkechi Onwuzurike, Hector M. Rodriguez-Cortes, Lisa M. Kopp, Hadi Sawaf, Thomas B. Russell, Robert M. Cooper, John R. Hill, Richard A. Drachtman, Alan C. Homans, Robert G. Irwin, Carla B. Golden, Douglas J. Scothorn, Cameron K. Tebbi, Fouad M. Hajjar, Judy L. Felgenhauer, Pamela H. Kempert, Minnie Abromowitch, Robert J. Fallon, Elaine R. Morgan, Gregory P. Brandt, Gregory A. Hale, Lisa M. McGregor, Robert I. Parker, Nichole L. Bryant, Wendy L. Woods-Swafford, Susan G. Kreissman, Steven K. Bergstrom, Jeffrey R. Andolina, Sara Chaffee, Philip M. Monteleone, Joel A. Kaplan, Gregory E. Halligan, Bassem I. Razzouk, Robert J. Hayashi, Tamra L. Slone, Janice F. Olson, Rebecca E. McFall, Michael K. Richards, Steven J. Kuerbitz, Bruce M. Camitta, Katharina E. Elliott, Jeffrey S. Lobel, Koh B. Boayue, Jeffrey H. Schwartz, Linda Granowetter, Mary A. Bonilla, Peter D. Cole, Teresa A. York, Jeffrey S. Dome, Melissa A. Forouhar, Maxine L. Hetherington, Steven L. Halpern, Susan R. Rheingold, Emad K. Salman, Stuart H. Gold, Rochelle A. Yanofsky, Lars M. Wagner, Aziza T. Shad, David L. Becton, Eugenia Chang, Samuel O. Anim, Bethany G. Sleckman, William B. Slayton, David S. Dickens, Alyssa T. Reddy, Yvan Samson, Alice Lee, Sharon B. Abish, Caron Strahlendorf, Jacqueline M. Halton, Shayna M. Zelcer, Conrad V. Fernandez, Mark J. Mogul
Related Therapeutic Areas
Sponsors
Leads: Children's Oncology Group
Collaborators: National Cancer Institute (NCI)